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This family is involved in biogenesis of respiratory and photosynthetic systems. SCO1 (P23833) is required for a post-translational step in the accumulation of subunits COXI and COXII of cytochrome c oxidase . SenC (Q52720) is required for optimal cytochrome c oxidase activity and maximal induction of genes encoding the light-harvesting and reaction centre complexes of R. capsulatus .
Buggy J, Bauer CE; , J Bacteriol 1995;177:6958-6965.: Cloning and characterization of senC, a gene involved in both aerobic respiration and photosynthesis gene expression in Rhodobacter capsulatus. PUBMED:7592491 EPMC:7592491
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This tab holds annotation information from the InterPro database.
InterPro entry IPR003782
This family is involved in biogenesis of respiratory and photosynthetic systems.
In yeast the SCO1 protein is specifically required for a post-translational step in the accumulation of subunits 1 and 2 of cytochrome c oxidase (COXI and COX-II) [PUBMED:1944230]. It is a mitochondrion-associated cytochrome c oxidase assembly factor. The SCOP homologue in Bacillus subtilis is also required for the expression of cytochrome c oxidase [PUBMED:10837475].
The purple nonsulphur photosynthetic eubacterium Rhodobacter capsulatus is a versatile organism that can obtain cellular energy by several means, including the capture of light energy for photosynthesis as well as the use of light-independent respiration, in which molecular oxygen serves as a terminal electron acceptor. The SenC protein is required for optimal cytochrome c oxidase activity in aerobically grown R. capsulatus cells and is involved in the induction of structural polypeptides of the light-harvesting and reaction centre complexes [PUBMED:7592491].
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Curation and family details
|Author:||Mian N, Bateman A|
|Number in seed:||6|
|Number in full:||2856|
|Average length of the domain:||164.20 aa|
|Average identity of full alignment:||24 %|
|Average coverage of the sequence by the domain:||74.44 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SCO1-SenC domain has been found. There are 30 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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