Summary: Chain length determinant protein
Chain length determinant protein Provide feedback
This family includes proteins involved in lipopolysaccharide (lps) biosynthesis. This family comprises the whole length of chain length determinant protein (or wzz protein) that confers a modal distribution of chain length on the O-antigen component of lps . This region is also found as part of bacterial tyrosine kinases such as P38134.
Franco AV, Liu D, Reeves PR; , J Bacteriol 1998;180:2670-2675.: The wzz (cld) protein in Escherichia coli: amino acid sequence variation determines O-antigen chain length specificity. PUBMED:9573151 EPMC:9573151
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This tab holds annotation information from the InterPro database.
InterPro entry IPR003856
A number of related proteins are involved in the synthesis of lipopolysaccharide, O-antigen polysaccharide, capsule polysaccharide and exopolysaccharides. Chain length determinant protein (or wzz protein) is involved in lipopolysaccharide (lps) biosynthesis, conferring a modal distribution of chain length on the O-antigen component of lps [PUBMED:9573151]. It gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 20. The MPA/MPA2 proteins function in CPS and EPS polymerisation and export [PUBMED:10658645].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||membrane (GO:0016020)|
|Biological process||lipopolysaccharide biosynthetic process (GO:0009103)|
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Curation and family details
|Seed source:||Pfam-B_1977 (release 5.5)|
|Author:||Bateman A, Mian N|
|Number in seed:||38|
|Number in full:||7377|
|Average length of the domain:||184.60 aa|
|Average identity of full alignment:||16 %|
|Average coverage of the sequence by the domain:||39.45 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Wzz domain has been found. There are 41 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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