Summary: Strictosidine synthase
Strictosidine synthase Provide feedback
Strictosidine synthase (E.C. 18.104.22.168) is a key enzyme in alkaloid biosynthesis. It catalyses the condensation of tryptamine with secologanin to form strictosidine.
Bracher D, Kutchan TM; , Arch Biochem Biophys 1992;294:717-723.: Strictosidine synthase from Rauvolfia serpentina: analysis of a gene involved in indole alkaloid biosynthesis. PUBMED:1567228 EPMC:1567228
Internal database links
|Similarity to PfamA using HHSearch:||Arylesterase SGL|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR018119
This entry represents a conserved region found in strictosidine synthase (EC), a key enzyme in alkaloid biosynthesis. It catalyses the Pictet-Spengler stereospecific condensation of tryptamine with secologanin to form strictosidine [PUBMED:18081287]. The structure of the native enzyme from the Indian medicinal plant Rauvolfia serpentina (Serpentwood) (Devilpepper) represents the first example of a six-bladed four-stranded beta-propeller fold from the plant kingdom [PUBMED:18280746].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||strictosidine synthase activity (GO:0016844)|
|Biological process||biosynthetic process (GO:0009058)|
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Curation and family details
|Seed source:||Pfam-B_1533 (release 6.5)|
|Number in seed:||8|
|Number in full:||707|
|Average length of the domain:||85.90 aa|
|Average identity of full alignment:||36 %|
|Average coverage of the sequence by the domain:||22.65 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Str_synth domain has been found. There are 14 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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