Summary: Gamma interferon inducible lysosomal thiol reductase (GILT)
Gamma interferon inducible lysosomal thiol reductase (GILT) Provide feedback
This family includes the two characterised human gamma-interferon-inducible lysosomal thiol reductase (GILT) sequences: P13284  and Q9UL08 . It also contains several other eukaryotic putative proteins with similarity to GILT . The aligned region contains three conserved cysteine residues. In addition, the two GILT sequences possess a C-X(2)-C motif that is shared by some of the other sequences in the family. This motif is thought to be associated with disulphide bond reduction.
Luster AD, Weinshank RL, Feinman R, Ravetch JV; , J Biol Chem 1988;263:12036-12043.: Molecular and biochemical characterization of a novel gamma-interferon-inducible protein. PUBMED:3136170 EPMC:3136170
Arunachalam B, Phan UT, Geuze HJ, Cresswell P; , Proc Natl Acad Sci U S A 2000;97:745-750.: Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT). PUBMED:10639150 EPMC:10639150
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR004911This family includes the two characterised human gamma-interferon-inducible lysosomal thiol reductase (GILT) sequences [PUBMED:3136170, PUBMED:10639150]. It also contains several other eukaryotic putative proteins with similarity to GILT [PUBMED:11491538]. The aligned region contains three conserved cysteine residues. In addition, the two GILT sequences possess a C-X(2)-C motif that is shared by some of the other sequences in the family. This motif is thought to be associated with disulphide bond reduction.
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Curation and family details
|Seed source:||Pfam-B_1477 (release 6.5)|
|Number in seed:||15|
|Number in full:||522|
|Average length of the domain:||107.30 aa|
|Average identity of full alignment:||27 %|
|Average coverage of the sequence by the domain:||45.18 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
|Download:||download the raw HMM for this family|
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