Summary: Ubiquinone biosynthesis protein COQ7
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Ubiquinone biosynthesis protein COQ7 Provide feedback
Members of this family contain two repeats of about 90 amino acids, that contains two conserved motifs. One of these DXEXXH may be part of an enzyme active site.
Internal database links
|SCOOP:||Mn_catalase Rubrerythrin DUF2383|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR011566Coq7 (also known as Clk-1) is a di-iron carboxylate protein occuring in both prokaryotes and eukaryotes that is essential for ubiquinone biosynthesis [PUBMED:8621692, PUBMED:9823893]. It has been implicated in the aging process as mutations in the Caenorhabditis elegans gene lead to increased lifespan [PUBMED:9020081]. Coq7 is a membrane-bound protein that functions as a monooxygenase to hydroxylate demethoxyubiquinone (2-methoxy-5-methyl-6-polyprenyl-1,4-benzoquinone) in the penultimate step of ubiquinone biosynthesis [PUBMED:11435415]. Biochemical studies indicate that NADH can serve directly as a reductant for catalytic activation of dioxygen and substrate oxidation by the enzyme, with no requirement for an additional reductase protein component [PUBMED:20923139]. This direct reaction with NADH is so far unique amongst members of the di-iron carboxylate protein family. This entry is specific for the bacterial Coq7 proteins.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Biological process||ubiquinone biosynthetic process (GO:0006744)|
|oxidation-reduction process (GO:0055114)|
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Curation and family details
|Seed source:||Pfam-B_3545 (release 6.5)|
|Number in seed:||47|
|Number in full:||840|
|Average length of the domain:||164.50 aa|
|Average identity of full alignment:||33 %|
|Average coverage of the sequence by the domain:||78.42 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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