Summary: Ribophorin I
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Ribophorin I is an essential subunit of oligosaccharyltransferase (OST), which is also known as Dolichyl-diphosphooligosaccharide--protein glycosyltransferase, ( EC:188.8.131.52). OST catalyses the transfer of an oligosaccharide from dolichol pyrophosphate to selected asparagine residues of nascent polypeptides as they are translocated into the lumen of the rough endoplasmic reticulum. Ribophorin I and OST48 are though to be responsible for OST catalytic activity . Both yeast and mammalian proteins are glycosylated but the sites are not conserved. Glycosylation may contribute towards general solubility but is unlikely to be involved in a specific biochemical function  Most family members are predicted to have a transmembrane helix at the C terminus of this region.
Hardt B, Aparicio R, Bause E; , Glycoconj J 2000;17:767-779.: The oligosaccharyltransferase complex from pig liver: cDNA cloning, expression and functional characterisation. PUBMED:11443278 EPMC:11443278
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR007676Ribophorin I is an essential subunit of oligosaccharyltransferase (OST), which is also known as dolichyl-diphosphooligosaccharide--protein glycosyltransferase, (EC). OST catalyses the transfer of an oligosaccharide from dolichol pyrophosphate to selected asparagine residues of nascent polypeptides as they are translocated into the lumen of the rough endoplasmic reticulum. Ribophorin I and OST48 are thought to be responsible for OST catalytic activity [PUBMED:11443278]. Both yeast and mammalian proteins are glycosylated but the sites are not conserved. Glycosylation may contribute towards general solubility but is unlikely to be involved in a specific biochemical function [PUBMED:7720878]. Most family members are predicted to have a transmembrane helix at the C terminus of this region.
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|Cellular component||endoplasmic reticulum (GO:0005783)|
|integral to membrane (GO:0016021)|
|Molecular function||dolichyl-diphosphooligosaccharide-protein glycotransferase activity (GO:0004579)|
|Biological process||protein glycosylation (GO:0006486)|
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|Number in seed:||40|
|Number in full:||386|
|Average length of the domain:||397.90 aa|
|Average identity of full alignment:||32 %|
|Average coverage of the sequence by the domain:||80.96 %|
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build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
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