Summary: ELMO/CED-12 family
This is the Wikipedia entry entitled "ELMO (protein)". More...
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ELMO (protein) Edit Wikipedia article
ELMO (Engulfment and Cell Motility) is a family of related proteins (~82 kDa) involved in intracellular signalling networks. These proteins have no intrinsic catalytic activity and instead function as adaptors which can regulate the activity of other proteins through their ability to mediate protein-protein interactions.
 Structure and function
The ELMO family are evolutionarily conserved orthologs of the C. elegans protein CED-12. All isoforms contain a series of armadillo repeats, which begin at the N-terminus and extend around two thirds of the way along the protein, as well as a C-terminal proline-rich motif and a central PH domain. They function as part of a protein complex with Dock180-related proteins to form a bipartite guanine nucleotide exchange factor for Rac (a member of the Rho family of small G proteins). The Dock180-ELMO interaction requires the ELMO PH domain and also involves binding of the ELMO proline-rich motif to the Dock180 SH3 domain.
- ^ Lu M, Ravichandran KS (2006). "Dock180-ELMO cooperation in Rac activation". Meth. Enzym. 406: 388–402. doi:10.1016/S0076-6879(06)06028-9. PMID 16472672.
- ^ Gumienny TL, Brugnera E, Tosello-Trampont AC, et al. (2001). "CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration". Cell 107 (1): 27–41. doi:10.1016/S0092-8674(01)00520-7. PMID 11595183.
- ^ Komander D, Patel M, Laurin M, et al. (September 2008). "An Alpha-Helical Extension of the ELMO1 Pleckstrin Homology Domain Mediates Direct Interaction to DOCK180 and Is Critical in Rac Signaling". Mol. Biol. Cell 19 (11): 4837–51. doi:10.1091/mbc.E08-04-0345. PMC 2575150. PMID 18768751. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2575150.
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ELMO/CED-12 family Provide feedback
This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells . ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.
Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS; , Cell 2001;107:27-41.: CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. PUBMED:11595183 EPMC:11595183
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR006816
This entry represents the ELMO (EnguLfment and Cell MOtility) domain, which is found in a number of eukaryotic proteins involved in the cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility, including CED-12, ELMO-1 and ELMO-2.
ELMO-1 and ELMO-2 are components of signalling pathways that regulate phagocytosis and cell migration and are mammalian orthologues of the Caenorhabditis elegans gene, ced-12 that is required for the engulfment of dying cells and cell migration. ELMO-1/2 act in association with DOCK1 and CRK. ELMO-1/2 interact with the SH3-domain of DOCK1 via an SH3-binding site to enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. ELMO-1/2 could be part of a complex with DOCK1 and Rac1 that could be required to activate Rac Rho small GTPases. Regulatory GTPases in the Ras superfamily employ a cycle of alternating GTP binding and hydrolysis, controlled by guanine nucleotide exchange factors and GTPase-activating proteins (GAPs), as essential features of their actions in cells. Within the Ras superfamily, the Arf family is composed of 30 members, including 22 Arf-like (Arl) proteins. The ELMO domain has been proposed to be a GAP domain for ARL2 and other members of the Arf family [PUBMED:17452337].
|Cellular component||cytoskeleton (GO:0005856)|
|Biological process||phagocytosis (GO:0006909)|
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Curation and family details
|Seed source:||Pfam-B_3095 (release 7.5)|
|Number in seed:||60|
|Number in full:||873|
|Average length of the domain:||171.00 aa|
|Average identity of full alignment:||26 %|
|Average coverage of the sequence by the domain:||34.37 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
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