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0  structures 169  species 0  interactions 186  sequences 3  architectures

Family: ATP-synt_10 (PF05176)

Summary: ATP10 protein

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This is the Wikipedia entry entitled "ATP10 protein". More...

ATP10 protein Edit Wikipedia article

ATP10 protein
Identifiers
Symbol ATP-synt_10
Pfam PF05176
InterPro IPR007849

In molecular biology, ATP10 protein (mitochondrial ATPase complex subunit ATP10) is an ATP synthase assembly factor. It is essential for the assembly of the mitochondrial F1-F0 complex. A yeast nuclear gene (ATP10) encodes a product that is essential for the assembly of a functional mitochondrial ATPase complex. Mutations in ATP10 induce a loss of rutamycin sensitivity in the mitochondrial ATPase, but do not affect the respiratory enzymes. ATP10 has a molecular weight of 30,293 Da and its primary structure is not related to any known subunit of the yeast or mammalian mitochondrial ATPase complexes. ATP10 is associated with the mitochondrial membrane. It is suggested that the ATP10 product is not a subunit of the ATPase complex but rather a protein required for the assembly of the F0 sector of the complex.[1]

References[edit]

  1. ^ Ackerman SH, Tzagoloff A (June 1990). "ATP10, a yeast nuclear gene required for the assembly of the mitochondrial F1-F0 complex". J. Biol. Chem. 265 (17): 9952–9. PMID 2141026. 

This article incorporates text from the public domain Pfam and InterPro IPR007849

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

ATP10 protein Provide feedback

ATP 10 is essential for the assembly of a functional mitochondrial ATPase complex [1].

Literature references

  1. Ackerman SH, Tzagoloff A; , J Biol Chem 1990;265:9952-9959.: ATP 10, a yeast nuclear gene required for the assembly of the mitochondrial F1-F0 complex. PUBMED:2141026 EPMC:2141026


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR007849

This entry represents the ATPase assembly factor ATP10 found in mitochondria, which is essential for the assembly of the mitochondrial F1-F0 complex. A yeast nuclear gene (ATP10) encodes a product that is essential for the assembly of a functional mitochondrial ATPase complex. Mutations in ATP10 induce a loss of rutamycin sensitivity in the mitochondrial ATPase, but do not affect the respiratory enzymes. ATP10 has an Mr of 30,293 and its primary structure is not related to any known subunit of the yeast or mammalian mitochondrial ATPase complexes. ATP10 is associated with the mitochondrial membrane. It is suggested that the ATP10 product is not a subunit of the ATPase complex but rather a protein required for the assembly of the F0 sector of the complex [PUBMED:2141026].

Gene Ontology

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Domain organisation

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Alignments

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(23)
Full
(186)
Representative proteomes NCBI
(174)
Meta
(20)
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(41)
RP35
(82)
RP55
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RP75
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  Seed
(23)
Full
(186)
Representative proteomes NCBI
(174)
Meta
(20)
RP15
(41)
RP35
(82)
RP55
(117)
RP75
(137)
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  Seed
(23)
Full
(186)
Representative proteomes NCBI
(174)
Meta
(20)
RP15
(41)
RP35
(82)
RP55
(117)
RP75
(137)
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

Pfam alignments:

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Seed source: Wood V
Previous IDs: none
Type: Family
Author: Wood V
Number in seed: 23
Number in full: 186
Average length of the domain: 237.20 aa
Average identity of full alignment: 27 %
Average coverage of the sequence by the domain: 80.37 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.9 21.9
Trusted cut-off 23.8 24.7
Noise cut-off 21.7 21.1
Model length: 253
Family (HMM) version: 9
Download: download the raw HMM for this family

Species distribution

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