Summary: GATA-type transcription activator, N-terminal
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GATA-type transcription activator, N-terminal Provide feedback
GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.
Malik TH, Von Stechow D, Bronson RT, Shivdasani RA; , Mol Cell Biol 2002;22:8592-8600.: Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes. PUBMED:12446778 EPMC:12446778
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR008013
GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutations are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function as transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This entry represents the N-terminal domain of the family of GATA transcription activators.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||nucleus (GO:0005634)|
|Molecular function||DNA binding (GO:0003677)|
|zinc ion binding (GO:0008270)|
|Biological process||positive regulation of transcription, DNA-dependent (GO:0045893)|
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Curation and family details
|Number in seed:||16|
|Number in full:||190|
|Average length of the domain:||155.00 aa|
|Average identity of full alignment:||39 %|
|Average coverage of the sequence by the domain:||41.19 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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