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0  structures 82  species 0  interactions 222  sequences 3  architectures

Family: Sarcoglycan_2 (PF05510)

Summary: Sarcoglycan alpha/epsilon

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This is the Wikipedia entry entitled "Sarcoglycan". More...

Sarcoglycan Edit Wikipedia article

Sarcoglycan beta/gamma/delta
Identifiers
Symbol Sarcoglycan_1
Pfam PF04790
InterPro IPR006875
Sarcoglycan alpha/epsilon
Identifiers
Symbol Sarcoglycan_2
Pfam PF05510
InterPro IPR008908

The sarcoglycans are a family of transmembrane proteins[1] (α, β, γ, δ or ε) involved in the protein complex responsible for connecting the muscle fibre cytoskeleton to the extracellular matrix, preventing damage to the muscle fibre sarcolemma through shearing forces.

The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains.[2][3]

The disorders caused by the mutations of the sarcoglycans are called sarcoglycanopathies. Mutations in the α, β, γ or δ genes (not ε) encoding these proteins can lead to the associated limb-girdle muscular dystrophy.

Genes[edit]

References[edit]

  1. ^ Sarcoglycans at the US National Library of Medicine Medical Subject Headings (MeSH)
  2. ^ Zheng Y, Chockalingam PS, Cholera R, Oak SA, Jarrett HW, Thomason DB (2002). "Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy". Am J Physiol Cell Physiol 283 (2): –. doi:10.1152/ajpcell.00529.2001. PMID 12107060. 
  3. ^ Wheeler MT, Zarnegar S, Mcnally EM (2002). "zeta-Sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy". Hum. Mol. Genet. 11 (18): 2147–2154. doi:10.1093/hmg/11.18.2147. PMID 12189167. 

This article incorporates text from the public domain Pfam and InterPro IPR006875


This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

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Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localisation of these proteins along the nonjunctional sarcolemma is not clear [1]. This family contains alpha and epsilon members.

Literature references

  1. Anastasi G, Cutroneo G, Trimarchi F, Rizzo G, Bramanti P, Bruschetta D, Fugazzotto D, Cinelli MP, Soscia A, Santoro G, Favaloro A; , Cells Tissues Organs 2003;173:54-63.: Sarcoglycans in human skeletal muscle and human cardiac muscle: a confocal laser scanning microscope study. PUBMED:12566627 EPMC:12566627


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR008908

Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localisation of these proteins along the nonjunctional sarcolemma is not clear [PUBMED:12566627]. This family contains alpha and epsilon members.

Gene Ontology

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Domain organisation

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  Seed
(5)
Full
(222)
Representative proteomes NCBI
(170)
Meta
(0)
RP15
(20)
RP35
(27)
RP55
(57)
RP75
(95)
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  Seed
(5)
Full
(222)
Representative proteomes NCBI
(170)
Meta
(0)
RP15
(20)
RP35
(27)
RP55
(57)
RP75
(95)
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

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Seed source: Pfam-B_9181 (release 8.0)
Previous IDs: sarcoglycan_2;
Type: Family
Author: Moxon SJ
Number in seed: 5
Number in full: 222
Average length of the domain: 320.00 aa
Average identity of full alignment: 44 %
Average coverage of the sequence by the domain: 91.77 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.2 28.1
Noise cut-off 25.6 24.3
Model length: 386
Family (HMM) version: 8
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