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0  structures 300  species 0  interactions 883  sequences 7  architectures

Family: PEX11 (PF05648)

Summary: Peroxisomal biogenesis factor 11 (PEX11)

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This is the Wikipedia entry entitled "Peroxisomal biogenesis factor 11". More...

Peroxisomal biogenesis factor 11 Edit Wikipedia article

Peroxisomal biogenesis factor 11 (PEX11)
Identifiers
Symbol PEX11
Pfam PF05648
InterPro IPR008733

Peroxisomal biogenesis factor 11 (PEX11) are peroxisomal membrane proteins which promote peroxisome division in eukaryotic cells.[1]

Human proteins from this family[edit]

PEX11A; PEX11B; PEX11G;

References[edit]

  1. ^ Gould SJ, Smith KD, Valle D, Li X, Baumgart E, Dong GX, Morrell JC, Jimenez-sanchez G (2002). "PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation". Mol. Cell. Biol. 22 (23): 8226–8240. PMC 134051. PMID 12417726. 

This article incorporates text from the public domain Pfam and InterPro IPR008733


This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Peroxisomal biogenesis factor 11 (PEX11) Provide feedback

This family consists of several peroxisomal biogenesis factor 11 (PEX11) proteins from several eukaryotic species. The PEX11 peroxisomal membrane proteins promote peroxisome division in multiple eukaryotes.

Literature references

  1. Li X, Baumgart E, Dong GX, Morrell JC, Jimenez-Sanchez G, Valle D, Smith KD, Gould SJ; , Mol Cell Biol 2002;22:8226-8240.: PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation. PUBMED:12417726 EPMC:12417726


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR008733

This family consists of several peroxisomal biogenesis factor 11 (PEX11) proteins from several eukaryotic species. The PEX11 peroxisomal membrane proteins promote peroxisome division in multiple eukaryotes [PUBMED:12417726]. PEX11 genes in rice have diversification not only in sequences but also in expression patterns under normal and various stress conditions [PUBMED:18291602].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(61)
Full
(883)
Representative proteomes NCBI
(829)
Meta
(5)
RP15
(168)
RP35
(289)
RP55
(432)
RP75
(540)
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Format an alignment

  Seed
(61)
Full
(883)
Representative proteomes NCBI
(829)
Meta
(5)
RP15
(168)
RP35
(289)
RP55
(432)
RP75
(540)
Alignment:
Format:
Order:
Sequence:
Gaps:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(61)
Full
(883)
Representative proteomes NCBI
(829)
Meta
(5)
RP15
(168)
RP35
(289)
RP55
(432)
RP75
(540)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

Pfam alignments:

HMM logo

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Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_2629 (release 8.0)
Previous IDs: none
Type: Family
Author: Moxon SJ
Number in seed: 61
Number in full: 883
Average length of the domain: 206.20 aa
Average identity of full alignment: 18 %
Average coverage of the sequence by the domain: 85.16 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.8 23.8
Trusted cut-off 23.8 23.8
Noise cut-off 23.6 23.7
Model length: 223
Family (HMM) version: 9
Download: download the raw HMM for this family

Species distribution

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