Summary: Apolipoprotein CIII (Apo-CIII)
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Apolipoprotein C3 Edit Wikipedia article
|RNA expression pattern|
ApoCIII is a relatively small protein containing 79 amino acids that can be glycosylated at threonine-74. The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal- GalNAc), further modified with up to 2 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties.
APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to inhibit hepatic uptake of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. Recent evidences suggest an intracellular role for Apo-CIII in promoting the assembly and secretion of triglyceride-rich VLDL particles from hepatic cells under lipid-rich conditions.  However, two naturally occurring point mutations in human apoC3 coding sequence, namely Ala23Thr and Lys58Glu have been shown to abolish the intracellular assembly and secretion of triglyceride-rich VLDL particles from hepatic cells. 
Two novel susceptibility haplotypes (specifically, P2-S2-X1 and P1-S2-X1) have been discovered in ApoAI-CIII-AIV gene cluster on chromosome 11q23; these confer approximately threefold higher risk of coronary heart disease in normal as well as non-insulin diabetes mellitus.Apo-CIII delays the catabolism of triglyceride rich particles. Elevations of Apo-CIII found in genetic variation studies may predispose patients to non-alcoholic fatty liver disease.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
- The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".
Apolipoprotein CIII is also on HDL partilcles.
- Vaith P, Assmann G, Uhlenbruck G (June 1978). "Characterization of the oligosaccharide side chain of apolipoprotein C-III from human plasma very low density lipoproteins". Biochim. Biophys. Acta 541 (2): 234–40. PMID 208636.
- Nicolardi S, van der Burgt YE, Dragan I, Hensbergen PJ, Deelder AM (May 2013). "Identification of new apolipoprotein-CIII glycoforms with ultrahigh resolution MALDI-FTICR mass spectrometry of human sera". J. Proteome Res. 12 (5): 2260–8. doi:10.1021/pr400136p. PMID 23527852.
- Mendivil CO, Zheng C, Furtado J, Lel J, Sacks FM (2009). "Metabolism of VLDL and LDL containing apolipoprotein C-III and not other small apolipoproteins – R2". Arteriosclerosis, Thrombosis and Vascular Biology 30 (2): 239–45. doi:10.1161/ATVBAHA.109.197830. PMC 2818784. PMID 19910636.
- Sundaram M, Zhong S, Bou Khalil M, Links PH, Zhao Y, Iqbal J, Hussain MM, Parks RJ, Wang Y, Yao Z. (2010). "Expression of apolipoprotein C-III in McA-RH7777 cells enhances VLDL assembly and secretion under lipid-rich conditions.". J Lipid Res. 51 (1): 150–161. doi:10.1194/M900346-JLR200. PMID 19622837.
- Sundaram M, Zhong S, Bou Khalil M, Zhou H, Jiang ZG, Zhao Y, Iqbal J, Hussain MM, Figeys D, Wang Y, Yao Z. (2010). "Functional analysis of the missense APOC3 mutation Ala23Thr associated with human hypotriglyceridemia.". J Lipid Res. 51 (6): 1524–1534. doi:10.1194/jlr.M005108. PMID 20097930.
- Qin W, Sundaram M, Wang Y, Zhou H, Zhong S, Chang CC, Manhas S, Yao EF, Parks RJ, McFie PJ, Stone SJ, Jiang ZG, Wang C, Figeys D, Jia W, Yao Z. (2011). "Missense mutation in APOC3 within the C-terminal lipid binding domain of human ApoC-III results in impaired assembly and secretion of triacylglycerol-rich very low density lipoproteins: evidence that ApoC-III plays a major role in the formation of lipid precursors within the microsomal lumen.". J Biol Chem. 286 (31): 27769–27780. doi:10.1074/jbc.M110.203679. PMID 21676879.
- Singh PP, Singh M, Kaur TP, Grewal SS (2007). "A novel haplotype in ApoAI-CIII-AIV gene region is detrimental to Northwest Indians with coronary heart disease". Int J Cardiol 130 (3): e93–5. doi:10.1016/j.ijcard.2007.07.029. PMID 17825930.
- Singh PP, Singh M, Gaur S, Grewal SS (2007). "The ApoAI-CIII-AIV gene cluster and its relation to lipid levels in type 2 diabetes mellitus and coronary heart disease: determination of a novel susceptible haplotype". Diab Vasc Dis Res 4 (2): 124–29. doi:10.3132/dvdr.2007.030. PMID 17654446.
- von Eckardstein A, Holz H, Sandkamp M (1991). "Apolipoprotein C-III(Lys58----Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia". J. Clin. Invest. 87 (5): 1724–31. doi:10.1172/JCI115190. PMC 295277. PMID 2022742.
- Karathanasis SK, Zannis VI, Breslow JL (1985). "Isolation and characterization of cDNA clones corresponding to two different human apoC-III alleles". J. Lipid Res. 26 (4): 451–6. PMID 2989400.
- Karathanasis SK, Oettgen P, Haddad IA, Antonarakis SE (1986). "Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4)". Proc. Natl. Acad. Sci. U.S.A. 83 (22): 8457–61. doi:10.1073/pnas.83.22.8457. PMC 386949. PMID 3095836.
- Maeda H, Hashimoto RK, Ogura T (1988). "Molecular cloning of a human apoC-III variant: Thr 74—Ala 74 mutation prevents O-glycosylation". J. Lipid Res. 28 (12): 1405–9. PMID 3123586.
- Karathanasis SK (1985). "Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes". Proc. Natl. Acad. Sci. U.S.A. 82 (19): 6374–8. doi:10.1073/pnas.82.19.6374. PMC 390718. PMID 3931073.
- Zannis VI, Cole FS, Jackson CL (1985). "Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues. Time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages". Biochemistry 24 (16): 4450–5. doi:10.1021/bi00337a028. PMID 3931677.
- Shelley CS, Sharpe CR, Baralle FE, Shoulders CC (1986). "Comparison of the human apolipoprotein genes. Apo AII presents a unique functional intron-exon junction". J. Mol. Biol. 186 (1): 43–51. doi:10.1016/0022-2836(85)90255-4. PMID 3935800.
- Hospattankar AV, Brewer HB, Ronan R, Fairwell T (1986). "Amino acid sequence of human plasma apolipoprotein C-III from normolipidemic subjects". FEBS Lett. 197 (1–2): 67–73. doi:10.1016/0014-5793(86)80300-3. PMID 3949020.
- Brewer HB, Shulman R, Herbert P (1974). "The complete amino acid sequence of alanine apolipoprotein (apoC-3), and apolipoprotein from human plasma very low density lipoproteins". J. Biol. Chem. 249 (15): 4975–84. PMID 4846755.
- Karathanasis SK, McPherson J, Zannis VI, Breslow JL (1983). "Linkage of human apolipoproteins A-I and C-III genes". Nature 304 (5924): 371–3. doi:10.1038/304371a0. PMID 6308458.
- Sharpe CR, Sidoli A, Shelley CS (1984). "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance". Nucleic Acids Res. 12 (9): 3917–32. doi:10.1093/nar/12.9.3917. PMC 318799. PMID 6328445.
- Law SW, Gray G, Brewer HB (1983). "cDNA cloning of human apoA-I: amino acid sequence of preproapoA-I". Biochem. Biophys. Res. Commun. 112 (1): 257–64. doi:10.1016/0006-291X(83)91824-7. PMID 6404278.
- Protter AA, Levy-Wilson B, Miller J (1985). "Isolation and sequence analysis of the human apolipoprotein CIII gene and the intergenic region between the apo AI and apo CIII genes". DNA 3 (6): 449–56. doi:10.1089/dna.1.1984.3.449. PMID 6439535.
- Levy-Wilson B, Appleby V, Protter A (1985). "Isolation and DNA sequence of full-length cDNA for human preapolipoprotein CIII". DNA 3 (5): 359–64. doi:10.1089/dna.1984.3.359. PMID 6548954.
- Dammerman M, Sandkuijl LA, Halaas JL (1993). "An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3' untranslated region polymorphisms". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4562–6. doi:10.1073/pnas.90.10.4562. PMC 46552. PMID 8099442.
- Wu JH, Kao JT, Wen MS, Lo SK (2000). "DNA polymorphisms at the apolipoprotein A1-CIII loci in Taiwanese: correlation of plasma APOCIII with triglyceride level and body mass index". J. Formos. Med. Assoc. 99 (5): 367–74. PMID 10870325.
- Geraci MW, Moore M, Gesell T (2001). "Gene expression patterns in the lungs of patients with primary pulmonary hypertension: a gene microarray analysis". Circ. Res. 88 (6): 555–62. doi:10.1161/01.RES.88.6.555. PMID 11282888.
- Inoue Y, Miyazaki M, Tsuji T (2002). "Reactivation of liver-specific gene expression in an immortalized human hepatocyte cell line by introduction of the human HNF4alpha2 gene". Int. J. Mol. Med. 8 (5): 481–7. PMID 11605014.
- Pastier D, Lacorte JM, Chambaz J (2002). "Two initiator-like elements are required for the combined activation of the human apolipoprotein C-III promoter by upstream stimulatory factor and hepatic nuclear factor-4". J. Biol. Chem. 277 (17): 15199–206. doi:10.1074/jbc.M200227200. PMID 11839757.
- Chhabra S, Narang R, Krishnan LR (Jun 2002). "Apolipoprotein C3 SstI polymorphism and triglyceride levels in Asian Indians". BMC Genet. 3: 9. doi:10.1186/1471-2156-3-9. PMC 116591. PMID 12052247.
This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.
Apolipoprotein CIII (Apo-CIII) Provide feedback
This family consists of several mammalian apolipoprotein CIII (Apo-CIII) sequences. Apolipoprotein C-III is a 79-residue glycoprotein. It is synthesised in the intestine and liver as part of the very low density lipoprotein (VLDL) and the high density lipoprotein (HDL) particles. Owing to its positive correlation with plasma triglyceride (Tg) levels, Apo-CIII is suggested to play a role in Tg metabolism and is therefore of interest regarding atherosclerosis. However, unlike other apolipoproteins such as Apo-AI, Apo E or CII for which many naturally occurring mutations are known, the structure-function relationships of apo C-III remains a subject of debate. One possibility is that apo C-III inhibits lipoprotein lipase (LPL) activity, as shown by in vitro experiments. Another suggestion, is that elevated levels of Apo-CIII displace other apolipoproteins at the lipoprotein surface, modifying their clearance from plasma .
Lins L, Flore C, Chapelle L, Talmud PJ, Thomas A, Brasseur R; , Protein Eng 2002;15:513-520.: Lipid-interacting properties of the N-terminal domain of human apolipoprotein C-III. PUBMED:12082170 EPMC:12082170
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR008403This family consists of several mammalian apolipoprotein CIII (Apo-CIII) sequences. Apolipoprotein C-III is a 79-residue glycoprotein. It is synthesised in the intestine and liver as part of the very low density lipoprotein (VLDL) and the high density lipoprotein (HDL) particles. Owing to its positive correlation with plasma triglyceride (Tg) levels, Apo-CIII is suggested to play a role in Tg metabolism and is therefore of interest regarding atherosclerosis. However, unlike other apolipoproteins such as Apo-AI, Apo E or CII for which many naturally occurring mutations are known, the structure-function relationships of apo C-III remains a subject of debate. One possibility is that apo C-III inhibits lipoprotein lipase (LPL) activity, as shown by in vitro experiments. Another suggestion, is that elevated levels of Apo-CIII displace other apolipoproteins at the lipoprotein surface, modifying their clearance from plasma [PUBMED:12082170].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||extracellular region (GO:0005576)|
|Molecular function||lipid binding (GO:0008289)|
|Biological process||lipid transport (GO:0006869)|
|lipoprotein metabolic process (GO:0042157)|
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Key: available, not generated, — not available.
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|Seed source:||Pfam-B_7283 (release 8.0)|
|Number in seed:||6|
|Number in full:||42|
|Average length of the domain:||65.00 aa|
|Average identity of full alignment:||61 %|
|Average coverage of the sequence by the domain:||62.42 %|
|HMM build commands:||
build method: hmmbuild --amino -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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Unmapped species names
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Apo-CIII domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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