Summary: Chordopoxvirus A33R protein
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Chordopoxvirus A33R protein Provide feedback
This family consists of several Chordopoxvirus A33R proteins. A33R plays a role in promoting Ab-resistant cell-to-cell spread of virus  and interacts with A36R to incorporate the protein into the outer membrane of intracellular enveloped virions (IEV) .
Law M, Hollinshead R, Smith GL; , J Gen Virol 2002;83:209-222.: Antibody-sensitive and antibody-resistant cell-to-cell spread by vaccinia virus: role of the A33R protein in antibody-resistant spread. PUBMED:11752718 EPMC:11752718
Ward BM, Weisberg AS, Moss B; , J Virol 2003;77:4113-4126.: Mapping and functional analysis of interaction sites within the cytoplasmic domains of the vaccinia virus A33R and A36R envelope proteins. PUBMED:12634370 EPMC:12634370
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR009238
This family consists of several Chordopoxvirus A33R proteins. A33R plays a role in promoting Ab-resistant cell-to-cell spread of virus [PUBMED:11752718] and interacts with A36R to incorporate the protein into the outer membrane of intracellular enveloped virions (IEV) [PUBMED:12634370].
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This clan contains domains that have a C-type lectin fold. Many of these are known or expected to mediate interactions with sugars.
The clan contains the following 7 members:APT C4 Chordopox_A33R Herpes_UL45 Intimin_C Lectin_C Xlink
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_4799 (release 9.0)|
|Number in seed:||6|
|Number in full:||66|
|Average length of the domain:||170.40 aa|
|Average identity of full alignment:||47 %|
|Average coverage of the sequence by the domain:||96.24 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Chordopox_A33R domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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