Summary: CodY GAF-like domain
This is the Wikipedia entry entitled "CodY protein family". More...
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CodY protein family Edit Wikipedia article
|c-terminal dna binding domain of transcriptional pleiotropic repressor cody.|
In molecular biology, the CodY protein family consists of several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions. The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk.
- Slack FJ, Serror P, Joyce E, Sonenshein AL (February 1995). "A gene required for nutritional repression of the Bacillus subtilis dipeptide permease operon". Mol. Microbiol. 15 (4): 689–702. PMID 7783641.
- Guedon E, Serror P, Ehrlich SD, Renault P, Delorme C (June 2001). "Pleiotropic transcriptional repressor CodY senses the intracellular pool of branched-chain amino acids in Lactococcus lactis". Mol. Microbiol. 40 (5): 1227–39. doi:10.1046/j.1365-2958.2001.02470.x. PMID 11401725.
CodY GAF-like domain Provide feedback
This domain is a GAF-like domain found at the N-terminus of several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. Presumably this domain is involved in GTP binding. CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions . The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk .
Slack FJ, Serror P, Joyce E, Sonenshein AL; , Mol Microbiol 1995;15:689-702.: A gene required for nutritional repression of the Bacillus subtilis dipeptide permease operon. PUBMED:7783641 EPMC:7783641
Guedon E, Serror P, Ehrlich SD, Renault P, Delorme C; , Mol Microbiol 2001;40:1227-1239.: Pleiotropic transcriptional repressor CodY senses the intracellular pool of branched-chain amino acids in Lactococcus lactis. PUBMED:11401725 EPMC:11401725
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR010312
This entry represents N-terminal domain of several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions [PUBMED:7783641, PUBMED:11331605]. The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk [PUBMED:11401725].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||DNA binding (GO:0003677)|
|GTP binding (GO:0005525)|
- the number of sequences which exhibit this architecture
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_7573 (release 9.0)|
|Author:||Moxon SJ, Bateman A|
|Number in seed:||17|
|Number in full:||1124|
|Average length of the domain:||176.60 aa|
|Average identity of full alignment:||45 %|
|Average coverage of the sequence by the domain:||67.49 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the CodY domain has been found. There are 9 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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