Summary: Isocitrate dehydrogenase kinase/phosphatase (AceK)
Isocitrate dehydrogenase kinase/phosphatase (AceK) Provide feedback
This family consists of several bacterial isocitrate dehydrogenase kinase/phosphatase (AceK) proteins ( EC:220.127.116.11) .
Nelson K, Wang FS, Boyd EF, Selander RK; , Genetics 1997;147:1509-1520.: Size and sequence polymorphism in the isocitrate dehydrogenase kinase/phosphatase gene (aceK) and flanking regions in Salmonella enterica and Escherichia coli. PUBMED:9409817 EPMC:9409817
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR010452
This family consists of several bacterial isocitrate dehydrogenase kinase/phosphatase (ICDH kinase/phosphatase) proteins. The enzyme has no activating compound but is specific for its substrate. It is a bifunctional enzyme that catalyses the reversible phosphorylation of isocitrate dehydrogenase (IDH, EC) on a seryl residue. It consequently belongs to the serine/threonine protein kinase family [PUBMED:11258918], and it acts in the Krebs cycle [PUBMED:11751849]. The catalytic activities of ICDH kinase/phosphatase constitute a moiety conserved cycle, require ATP, and exhibit 'zero-order ultrasensitivity' [PUBMED:16415587].
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|Cellular component||cytoplasm (GO:0005737)|
|Molecular function||phosphatase activity (GO:0016791)|
|[isocitrate dehydrogenase (NADP+)] kinase activity (GO:0008772)|
|Biological process||glucose metabolic process (GO:0006006)|
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Curation and family details
|Seed source:||Pfam-B_13100 (release 9.0)|
|Number in seed:||39|
|Number in full:||830|
|Average length of the domain:||541.90 aa|
|Average identity of full alignment:||62 %|
|Average coverage of the sequence by the domain:||96.03 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the AceK domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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