Summary: ComK protein
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This family consists of several bacterial ComK proteins. The ComK protein of Bacillus subtilis positively regulates the transcription of several late competence genes as well as comK itself. It has been found that ClpX plays an important role in the regulation of ComK at the post-transcriptional level .
Nanamiya H, Shiomi E, Ogura M, Tanaka T, Asai K, Kawamura F; , J Biochem (Tokyo) 2003;133:295-302.: Involvement of ClpX Protein in the Post-Transcriptional Regulation of a Competence Specific Transcription Factor, ComK Protein, of Bacillus subtilis. PUBMED:12761164 EPMC:12761164
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This tab holds annotation information from the InterPro database.
InterPro entry IPR010461
Competence is the ability of a cell to take up exogenous DNA from its environment, resulting in transformation. It is widespread among bacteria and is probably an important mechanism for the horizontal transfer of genes. Cells that take up DNA inevitably acquire the nucleotides the DNA consists of, and, because nucleotides are needed for DNA and RNA synthesis and are expensive to synthesise, these may make a significant contribution to the cell's energy budget [PUBMED:11483988]. The lateral gene transfer caused by competence also contributes to the genetic diversity that makes evolution possible.
DNA usually becomes available by the death and lysis of other cells. Competent bacteria use components of extracellular filaments called type 4 pili to create pores in their membranes and pull DNA through the pores into the cytoplasm. This process, including the development of competence and the expression of the uptake machinery, is regulated in response to cell-cell signalling and/or nutritional conditions [PUBMED:8901420].
This family consists of several bacterial ComK proteins. ComK of Bacillus subtilis is a positive autoregulatory protein occupying a central position in the competence-signal-transduction network. It positively regulates the transcription of late competence genes, which specify morphogenetic and structural proteins necessary for construction of the DNA-binding and uptake apparatus, as well as the transcription of comK itself [PUBMED:12761164,PUBMED:7783616]. ComK specifically binds to the promoters of the genes that it affects. It has been found that ClpX plays an important role in the regulation of ComK at the post-transcriptional level [PUBMED:12761164].
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Curation and family details
|Seed source:||Pfam-B_13324 (release 9.0)|
|Number in seed:||19|
|Number in full:||719|
|Average length of the domain:||150.30 aa|
|Average identity of full alignment:||29 %|
|Average coverage of the sequence by the domain:||87.47 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
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