Summary: Euplotes raikovi mating pheromone
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Euplotes raikovi mating pheromone Provide feedback
This family consists of several Euplotes raikovi mating pheromone proteins. Diffusible polypeptide pheromones, which distinguish otherwise morphologically identical vegetative cell types from one another, are produced by some species of ciliates. In the marine sand-dwelling protozoan ciliate Euplotes raikovi, pheromone molecules promote the vegetative reproduction (mitogenic proliferation or growth) of the same cells from which they originate. As, understandably, such autocrine pheromone activity is primary to that of targeting and inducing a foreign cell to mate (paracrine functions), this finding provides an example of how the original function of a molecule can be obscured during evolution by the acquisition of a new one .
Miceli C, La Terza A, Bradshaw RA, Luporini P; , Eur J Biochem 1991;202:759-764.: Structural characterization of mating pheromone precursors of the ciliate protozoan Euplotes raikovi. High conservation of pre and pro regions versus high variability of secreted regions. PUBMED:1722455 EPMC:1722455
Weiss MS, Anderson DH, Raffioni S, Bradshaw RA, Ortenzi C, Luporini P, Eisenberg D; , Proc Natl Acad Sci U S A 1995;92:10172-10176.: A cooperative model for receptor recognition and cell adhesion: evidence from the molecular packing in the 1.6-A crystal structure of the pheromone Er-1 from the ciliated protozoan Euplotes raikovi. PUBMED:7479748 EPMC:7479748
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This tab holds annotation information from the InterPro database.
InterPro entry IPR009064
Protozoan pheromones are cell-type specific protein signals. This entry represents a family of mating ciliate pheromones (or gamones) from the protozoan Euplotes raikovi, including Er-1, Er-2, Er-10, Er11 and Er22. These pheromones are diffusible extracellular communication signals that distinguish different intra-specific classes of cells commonly referred to as 'mating types'. Pheromones prepare these cells for conjugation by changing their cell surface properties. The mitogenic activity induced by Er pheromone autocrine signalling can be inhibited by cAMP [PUBMED:12681291]. The NMR structure of several pheromones have been determined, revealing a closed up-and-down bundle of three helices with a left-handed twist [PUBMED:7833812, PUBMED:7833811, PUBMED:8515452, PUBMED:8844842, PUBMED:11246857]. In some cases, different pheromones can compete with each other in binding to their cell-surface receptors.
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|Seed source:||Pfam-B_14708 (release 9.0)|
|Number in seed:||6|
|Number in full:||6|
|Average length of the domain:||35.30 aa|
|Average identity of full alignment:||37 %|
|Average coverage of the sequence by the domain:||62.72 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the E_raikovi_mat domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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