Summary: Zeta toxin
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Zeta toxin Provide feedback
This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid .
Meinhart A, Alonso JC, Strater N, Saenger W; , Proc Natl Acad Sci U S A 2003;100:1661-1666.: Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation. PUBMED:12571357 EPMC:12571357
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR010488
This entry represents a domain originally identified in bacterial zeta toxin proteins, where it comprises the whole protein [PUBMED:12571357]. It has subsequently been found in a number of other proteins, such as polynucleotide kinase and 2',3'-cyclic-nucleotide 3'-phosphodiesterase. It appears to function as a kinase domain [PUBMED:12220496, PUBMED:21445328].
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|Molecular function||ATP binding (GO:0005524)|
|kinase activity (GO:0016301)|
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Curation and family details
|Seed source:||Pfam-B_12374 (release 9.0)|
|Number in seed:||40|
|Number in full:||1247|
|Average length of the domain:||168.70 aa|
|Average identity of full alignment:||21 %|
|Average coverage of the sequence by the domain:||56.57 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Zeta_toxin domain has been found. There are 8 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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