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7  structures 27  species 1  interaction 40  sequences 1  architecture

Family: Olfactory_mark (PF06554)

Summary: Olfactory marker protein

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This is the Wikipedia entry entitled "Olfactory marker protein". More...

Olfactory marker protein Edit Wikipedia article

olfactory marker protein
Identifiers
Symbol OMP
Entrez 4975
HUGO 8136
OMIM 164340
RefSeq NM_006189
UniProt P47874
Other data
Locus Chr. 11 q14-q21
Olfactory marker protein
PDB 1jyt EBI.jpg
solution structure of olfactory marker protein from rat
Identifiers
Symbol Olfactory_mark
Pfam PF06554
InterPro IPR009103
SCOP 1jyt
SUPERFAMILY 1jyt

In molecular biology, olfactory marker protein is a protein involved in signal transduction. It is a highly expressed, cytoplasmic protein found in mature olfactory sensory receptor neurons of all vertebrates. OMP is a modulator of the olfactory signal transduction cascade. The crystal structure of OMP reveals a beta sandwich consisting of eight strands in two sheets with a jelly-roll topology.[1] Three highly conserved regions have been identified as possible protein-protein interaction sites in OMP, indicating a possible role for OMP in modulating such interactions, thereby acting as a molecular switch.[2]

External links[edit]

References[edit]

  1. ^ Baldisseri DM, Margolis JW, Weber DJ, Koo JH, Margolis FL (June 2002). "Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction". J. Mol. Biol. 319 (3): 823–37. doi:10.1016/S0022-2836(02)00282-6. PMID 12054873. 
  2. ^ Smith PC, Firestein S, Hunt JF (June 2002). "The crystal structure of the olfactory marker protein at 2.3 A resolution". J. Mol. Biol. 319 (3): 807–21. doi:10.1016/S0022-2836(02)00242-5. PMID 12054872. 

This article incorporates text from the public domain Pfam and InterPro IPR009103

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Olfactory marker protein Provide feedback

This family consists of several olfactory marker proteins. Expression of the olfactory marker protein (OMP) is highly restricted to mature olfactory receptor neurons in virtually all vertebrate species from fish to man.

Literature references

  1. Buiakova OI, Krishna NS, Getchell TV, Margolis FL; , Genomics 1994;20:452-462.: Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization. PUBMED:8034318 EPMC:8034318


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR009103

Olfactory marker protein (OMP) is a highly expressed, cytoplasmic protein found in mature olfactory sensory receptor neurons of all vertebrates. OMP is a modulator of the olfactory signal transduction cascade. The crystal structure of OMP reveals a beta sandwich consisting of eight strands in two sheets with a jelly-roll topology [PUBMED:12054873]. Three highly conserved regions have been identified as possible protein-protein interaction sites in OMP, indicating a possible role for OMP in modulating such interactions, thereby acting as a molecular switch [PUBMED:12054872].

Gene Ontology

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Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

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(4)
Full
(40)
Representative proteomes NCBI
(43)
Meta
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(1)
RP35
(4)
RP55
(8)
RP75
(9)
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  Seed
(4)
Full
(40)
Representative proteomes NCBI
(43)
Meta
(0)
RP15
(1)
RP35
(4)
RP55
(8)
RP75
(9)
Alignment:
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Sequence:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(4)
Full
(40)
Representative proteomes NCBI
(43)
Meta
(0)
RP15
(1)
RP35
(4)
RP55
(8)
RP75
(9)
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

Pfam alignments:

HMM logo

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Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_18049 (release 10.0)
Previous IDs: none
Type: Family
Author: Moxon SJ
Number in seed: 4
Number in full: 40
Average length of the domain: 138.60 aa
Average identity of full alignment: 65 %
Average coverage of the sequence by the domain: 94.58 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 76.6 76.5
Noise cut-off 19.1 17.7
Model length: 151
Family (HMM) version: 7
Download: download the raw HMM for this family

Species distribution

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Interactions

There is 1 interaction for this family. More...

Olfactory_mark

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Olfactory_mark domain has been found. There are 7 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.

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