Summary: NOTCH protein
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NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals [1-2]. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.
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This tab holds annotation information from the InterPro database.
InterPro entry IPR010660
NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals [PUBMED:10221902]. NOD (NOTCH protein domain) represents a region present in many NOTCH proteins and NOTCH homologues in multiple species such as 0, NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.
|Cellular component||integral to membrane (GO:0016021)|
|Biological process||cell differentiation (GO:0030154)|
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Curation and family details
|Seed source:||Guo J|
|Previous IDs:||NOD; NOD1;|
|Author:||Guo J, Studholme DJ|
|Number in seed:||26|
|Number in full:||289|
|Average length of the domain:||56.10 aa|
|Average identity of full alignment:||43 %|
|Average coverage of the sequence by the domain:||2.77 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the NOD domain has been found. There are 8 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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