Summary: Rotavirus VP3 protein
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Rotavirus VP3 protein Provide feedback
This family consists of several Rotavirus specific VP3 proteins. VP3 is known to be a viral guanylyltransferase and is thought to posses methyltransferase activity and therefore VP3 is a predicted multifunctional capping enzyme .
Chen D, Luongo CL, Nibert ML, Patton JT; , Virology 1999;265:120-130.: Rotavirus open cores catalyze 5'-capping and methylation of exogenous RNA: evidence that VP3 is a methyltransferase. PUBMED:10603323 EPMC:10603323
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR011181Viral protein 3 (VP3) specifically binds to GTP and contains mRNA guanylyltransferase and mRNA (guanine-N(7)-)-methyltransferase activities. It is a multifunctional enzyme involved in mRNA capping. It catalyses the formation of the 5' cap structure on the viral plus-strand transcripts [PUBMED:10603323].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||viral nucleocapsid (GO:0019013)|
|Molecular function||GTP binding (GO:0005525)|
|Biological process||viral reproduction (GO:0016032)|
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Curation and family details
|Seed source:||Pfam-B_14798 (release 10.0)|
|Number in seed:||3|
|Number in full:||582|
|Average length of the domain:||551.40 aa|
|Average identity of full alignment:||85 %|
|Average coverage of the sequence by the domain:||83.42 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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