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0  structures 41  species 0  interactions 78  sequences 1  architecture

Family: Osteoregulin (PF07175)

Summary: Osteoregulin

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "MEPE". More...

MEPE Edit Wikipedia article

Matrix extracellular phosphoglycoprotein
Identifiers
Symbols MEPE; OF45
External IDs OMIM605912 MGI2137384 HomoloGene10623 GeneCards: MEPE Gene
RNA expression pattern
PBB GE MEPE 221150 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 56955 94111
Ensembl ENSG00000152595 ENSMUSG00000053863
UniProt Q9NQ76 Q8K4L6
RefSeq (mRNA) NM_001184694 NM_053172
RefSeq (protein) NP_001171623 NP_444402
Location (UCSC) Chr 4:
88.74 – 88.77 Mb
Chr 5:
104.33 – 104.34 Mb
PubMed search [1] [2]
Osteoregulin
Identifiers
Symbol Osteoregulin
Pfam PF07175
InterPro IPR009837

Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) is a protein that in humans is encoded by the MEPE gene.[1][2] A conserved RGD motif is found in this protein, and this is potentially involved in integrin recognition.[3]


References[edit]

  1. ^ Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL (1 July 2000,). "MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia". Genomics 67 (1): 54–68. doi:10.1006/geno.2000.6235. PMID 10945470. 
  2. ^ "Entrez Gene: MEPE matrix, extracellular phosphoglycoprotein with ASARM motif (bone)". 
  3. ^ Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R, Brown TA (November 2000). "Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes". J. Biol. Chem. 275 (46): 36172–80. doi:10.1074/jbc.M003622200. PMID 10967096. 

Further reading[edit]

  • Quarles LD (2003). "FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization.". Am. J. Physiol. Endocrinol. Metab. 285 (1): E1–9. doi:10.1152/ajpendo.00016.2003. PMID 12791601. 
  • Ogbureke KU, Fisher LW (2005). "Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs).". Kidney Int. 68 (1): 155–66. doi:10.1111/j.1523-1755.2005.00389.x. PMID 15954904. 
  • Ogbureke KU, Fisher LW (2004). "Expression of SIBLINGs and their partner MMPs in salivary glands.". J. Dent. Res. 83 (9): 664–70. doi:10.1177/154405910408300902. PMID 15329369. 
  • Jain A, Fedarko NS, Collins MT, et al. (2004). "Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density.". J. Clin. Endocrinol. Metab. 89 (8): 4158–61. doi:10.1210/jc.2003-032031. PMID 15292364. 
  • Nampei A, Hashimoto J, Hayashida K, et al. (2005). "Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone.". J. Bone Miner. Metab. 22 (3): 176–84. doi:10.1007/s00774-003-0468-9. PMID 15108058. 
  • MacDougall M, Simmons D, Gu TT, Dong J (2003). "MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21.". Connect. Tissue Res. 43 (2-3): 320–30. doi:10.1080/713713461. PMID 12489176. 
  • Argiro L, Desbarats M, Glorieux FH, Ecarot B (2001). "Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone.". Genomics 74 (3): 342–51. doi:10.1006/geno.2001.6553. PMID 11414762. 

This article incorporates text from the public domain Pfam and InterPro IPR009837

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Osteoregulin Provide feedback

This family represents a conserved region approximately 180 residues long within osteoregulin, a bone-remodelling protein expressed highly in osteocytes within trabecular and cortical bone. A conserved RGD motif is found towards the C-terminal end of this region, and this is potentially involved in integrin recognition [1].

Literature references

  1. Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R, Brown TA; , J Biol Chem 2000;275:36172-36180.: Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes. PUBMED:10967096 EPMC:10967096


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR009837

This family represents a conserved region approximately 180 residues long within osteoregulin, a bone-remodelling protein expressed highly in osteocytes within trabecular and cortical bone. A conserved RGD motif is found towards the C-terminal end of this region, and this is potentially involved in integrin recognition [PUBMED:10967096].

Domain organisation

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Alignments

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

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(3)
Full
(78)
Representative proteomes NCBI
(72)
Meta
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(1)
RP35
(1)
RP55
(1)
RP75
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  Seed
(3)
Full
(78)
Representative proteomes NCBI
(72)
Meta
(0)
RP15
(1)
RP35
(1)
RP55
(1)
RP75
(14)
Alignment:
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Sequence:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(3)
Full
(78)
Representative proteomes NCBI
(72)
Meta
(0)
RP15
(1)
RP35
(1)
RP55
(1)
RP75
(14)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

Pfam alignments:

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This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_16589 (release 10.0)
Previous IDs: none
Type: Family
Author: Vella Briffa B
Number in seed: 3
Number in full: 78
Average length of the domain: 174.70 aa
Average identity of full alignment: 55 %
Average coverage of the sequence by the domain: 34.65 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.1 22.1
Trusted cut-off 22.6 38.9
Noise cut-off 22.0 22.0
Model length: 163
Family (HMM) version: 6
Download: download the raw HMM for this family

Species distribution

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