Summary: Neurotensin/neuromedin N precursor
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This family contains the precursor of bacterial neurotensin/neuromedin N (approximately 170 residues long). This the common precursor of two biologically active related peptides, neurotensin and neuromedin N. It undergoes tissue-specific processing leading to the formation in some tissues and cancer cell lines of large peptides ending with the neurotensin or neuromedin N sequence .
Friry C, Feliciangeli S, Richard F, Kitabgi P, Rovere C; , Biochem Biophys Res Commun 2002;290:1161-1168.: Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity. PUBMED:11811984 EPMC:11811984
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This tab holds annotation information from the InterPro database.
InterPro entry IPR008055
Neurotensin is a 13-residue peptide transmitter, sharing significant similarity in its 6 C-terminal amino acid residues with several other neuropeptides, including neuromedin N (which is derived from the same precursor). This C-terminal region is responsible for the full biological activity, the N-terminal portion having a modulatory role.
Neurotensin is distributed throughout the central nervous system, with highest levels in the hypothalamus, amygdala and nucleus accumbens. It induces a variety of effects, including: analgesia, hypothermia and increased locomotor activity. It is also involved in regulation of dopamine pathways. In the periphery, neurotensin is found in endocrine cells of the small intestine, where it leads to secretion and smooth muscle contraction [PUBMED:11811984]. The neurotensin/neuromedin N precursor can also be processed to produce large 125-138 amino acid peptides with the neurotensin or neuromedin N sequence at their C terminus. These large peptides appear to be less potent than their smaller counterparts, but are also less sensitive to degradation and may represent endogenous, long-lasting activators in a number of pathophysiological situations.
|Cellular component||extracellular region (GO:0005576)|
|Molecular function||neuropeptide hormone activity (GO:0005184)|
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|Seed source:||Pfam-B_20947 (release 10.0)|
|Author:||Vella Briffa B|
|Number in seed:||3|
|Number in full:||47|
|Average length of the domain:||151.40 aa|
|Average identity of full alignment:||68 %|
|Average coverage of the sequence by the domain:||98.12 %|
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build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
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