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0  structures 210  species 0  interactions 564  sequences 70  architectures

Family: Glug (PF07581)

Summary: The GLUG motif

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

The GLUG motif Provide feedback

This family is found in the IgA1 (M26) peptidases, which attached to the cell wall peptidoglycan by an amide bond ([1]). IgA1 protease selectively cleaves human IgA1 and is likely to be a pathogenicity factor in some pathogens ([2]). This family is also found in various other contexts, including with PF05860. It is named GLUG after the mostly conserved G-L-any-G motif.

Literature references

  1. Poulsen K, Reinholdt J, Kilian M; , Infect Immun 1996;64:3957-3966.: Characterization of the Streptococcus pneumoniae immunoglobulin A1 protease gene (iga) and its translation product. PUBMED:8926055 EPMC:8926055

  2. Chiavolini D, Memmi G, Maggi T, Iannelli F, Pozzi G, Oggioni MR; , BMC Microbiol 2003;3:14.: The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice. PUBMED:12841855 EPMC:12841855


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR011493

This domain is found in the IgA1-specific metalloendopeptidases, which attach to the cell wall peptidoglycan by an amide bond [PUBMED:8926055]. IgA1 protease selectively cleaves human IgA1 and is likely to be a pathogenicity factor in some pathogens including Giardia spp [PUBMED:12841855]. This domain is also found in various other contexts, including with INTERPRO. It is named GLUG after the mostly conserved G-L-any-G motif.

The IgA1-specific metalloendopeptidases belong to MEROPS peptidase family M26, clan MA(E).

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(110)
Full
(564)
Representative proteomes NCBI
(551)
Meta
(145)
RP15
(77)
RP35
(158)
RP55
(178)
RP75
(192)
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PP/heatmap 1 View  View  View  View  View     
Pfam viewer View  View             

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(110)
Full
(564)
Representative proteomes NCBI
(551)
Meta
(145)
RP15
(77)
RP35
(158)
RP55
(178)
RP75
(192)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(110)
Full
(564)
Representative proteomes NCBI
(551)
Meta
(145)
RP15
(77)
RP35
(158)
RP55
(178)
RP75
(192)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

Pfam alignments:

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Yeats C
Previous IDs: none
Type: Family
Author: Yeats C
Number in seed: 110
Number in full: 564
Average length of the domain: 27.50 aa
Average identity of full alignment: 37 %
Average coverage of the sequence by the domain: 4.06 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.5 18.0
Trusted cut-off 20.5 18.0
Noise cut-off 20.4 17.9
Model length: 28
Family (HMM) version: 7
Download: download the raw HMM for this family

Species distribution

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