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0  structures 82  species 0  interactions 222  sequences 5  architectures

Family: FEZ (PF07763)

Summary: FEZ-like protein

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This is the Wikipedia entry entitled "FEZ-like protein". More...

FEZ-like protein Edit Wikipedia article

FEZ-like protein
Identifiers
Symbol FEZ
Pfam PF07763
InterPro IPR011680

In molecular biology, the FEZ-like protein family is a family of eukaryotic proteins thought to be involved in axonal outgrowth and fasciculation.[1] The N-terminal regions of these sequences are less conserved than the C-terminal regions, and are highly acidic.[1] The Caenorhabditis elegans homologue, UNC-76, may play structural and signalling roles in the control of axonal extension and adhesion (particularly in the presence of adjacent neuronal cells[2]) and these roles have also been postulated for other FEZ family proteins.[1] Certain homologues have been definitively found to interact with the N-terminal variable region (V1) of PKC-zeta, and this interaction causes cytoplasmic translocation of the FEZ family protein in mammalian neuronal cells.[2] The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta.[2] The members of this family are predicted to form coiled-coil structures[2][3] which may interact with members of the RhoA family of signalling proteins,[2] but are not thought to contain other characteristic protein motifs.[3] Certain members of this family are expressed almost exclusively in the brain, whereas others (such as FEZ2) are expressed in other tissues, and are thought to perform similar but unknown functions in these tissues.[3]

References[edit]

  1. ^ a b c Bloom L, Horvitz HR (April 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3414–9. doi:10.1073/pnas.94.7.3414. PMC 20384. PMID 9096408. 
  2. ^ a b c d e Kuroda S, Nakagawa N, Tokunaga C, Tatematsu K, Tanizawa K (February 1999). "Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein". J. Cell Biol. 144 (3): 403–11. doi:10.1083/jcb.144.3.403. PMC 2132904. PMID 9971736. 
  3. ^ a b c Fujita T, Ikuta J, Hamada J, Okajima T, Tatematsu K, Tanizawa K, Kuroda S (January 2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. 313 (3): 738–44. doi:10.1016/j.bbrc.2003.12.006. PMID 14697253. 

This article incorporates text from the public domain Pfam and InterPro IPR011680

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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

FEZ-like protein Provide feedback

This is a family of eukaryotic proteins thought to be involved in axonal outgrowth and fasciculation [1]. The N-terminal regions of these sequences are less conserved than the C-terminal regions, and are highly acidic [1]. The C. elegans homolog, UNC-76 (Q7JNU9), may play structural and signalling roles in the control of axonal extension and adhesion (particularly in the presence of adjacent neuronal cells [2]) and these roles have also been postulated for other FEZ family proteins [1]. Certain homologs have been definitively found to interact with the N-terminal variable region (V1) of PKC-zeta, and this interaction causes cytoplasmic translocation of the FEZ family protein in mammalian neuronal cells [2]. The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta [2]. The members of this family are predicted to form coiled-coil structures [2,3], which may interact with members of the RhoA family of signalling proteins [2] but are not thought to contain other characteristic protein motifs [3]. Certain members of this family are expressed almost exclusively in the brain, whereas others (such as FEZ2, Q76LN0) are expressed in other tissues, and are thought to perform similar but unknown functions in these tissues [3].

Literature references

  1. Bloom L, Horvitz HR; , Proc Natl Acad Sci U S A 1997;94:3414-3419.: The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. PUBMED:9096408 EPMC:9096408

  2. Kuroda S, Nakagawa N, Tokunaga C, Tatematsu K, Tanizawa K; , J Cell Biol 1999;144:403-411.: Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. PUBMED:9971736 EPMC:9971736

  3. Fujita T, Ikuta J, Hamada J, Okajima T, Tatematsu K, Tanizawa K, Kuroda S; , Biochem Biophys Res Commun 2004;313:738-744.: Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. PUBMED:14697253 EPMC:14697253


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR011680

This is a family of eukaryotic proteins thought to be involved in axonal outgrowth and fasciculation [PUBMED:9096408]. The N-terminal regions of these sequences are less conserved than the C-terminal regions, and are highly acidic [PUBMED:9096408]. The Caenorhabditis elegans homolog, UNC-76 (SWISSPROT), may play structural and signalling roles in the control of axonal extension and adhesion (particularly in the presence of adjacent neuronal cells [PUBMED:9971736]) and these roles have also been postulated for other FEZ family proteins [PUBMED:9096408]. Certain homologs have been definitively found to interact with the N-terminal variable region (V1) of PKC-zeta, and this interaction causes cytoplasmic translocation of the FEZ family protein in mammalian neuronal cells [PUBMED:9971736]. The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta [PUBMED:9971736]. The members of this family are predicted to form coiled-coil structures [PUBMED:9971736, PUBMED:14697253], which may interact with members of the RhoA family of signalling proteins [PUBMED:9971736], but are not thought to contain other characteristic protein motifs [PUBMED:14697253]. Certain members of this family are expressed almost exclusively in the brain, whereas others (such as FEZ2, SWISSPROT) are expressed in other tissues, and are thought to perform similar but unknown functions in these tissues [PUBMED:14697253].

Domain organisation

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  Seed
(10)
Full
(222)
Representative proteomes NCBI
(181)
Meta
(0)
RP15
(31)
RP35
(41)
RP55
(69)
RP75
(108)
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  Seed
(10)
Full
(222)
Representative proteomes NCBI
(181)
Meta
(0)
RP15
(31)
RP35
(41)
RP55
(69)
RP75
(108)
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External links

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Seed source: Pfam-B_8854 (release 14.0)
Previous IDs: none
Type: Family
Author: Fenech M
Number in seed: 10
Number in full: 222
Average length of the domain: 207.80 aa
Average identity of full alignment: 46 %
Average coverage of the sequence by the domain: 62.63 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 28.1 28.1
Trusted cut-off 28.4 29.5
Noise cut-off 26.3 28.0
Model length: 244
Family (HMM) version: 8
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