Summary: RED-like protein C-terminal region
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RED-like protein C-terminal region Provide feedback
This family contains sequences that are similar to the C-terminal region of Red protein (Q13123). This and related proteins are thought to be localised to the nucleus, and contain a RED repeat which consists of a number of RE and RD sequence elements . The region in question has several conserved NLS sequences . The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its expression may be tightly regulated or that the protein self-aggregates extremely efficiently .
Assier E, Bouzinba-Segard H, Stolzenberg MC, Stephens R, Bardos J, Freemont P, Charron D, Trowsdale J, Rich T; , Gene 1999;230:145-154.: Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat. PUBMED:10216252 EPMC:10216252
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR012492
This domain is found at the C terminus of Red protein (SWISSPROT). This and related proteins are thought to be localised to the nucleus, and contain a RED repeat which consists of a number of RE and RD sequence elements [PUBMED:10216252]. The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its expression may be tightly regulated or that the protein self-aggregates extremely efficiently [PUBMED:10216252].
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Curation and family details
|Seed source:||Pfam-B_9789 (release 14.0)|
|Number in seed:||7|
|Number in full:||152|
|Average length of the domain:||113.50 aa|
|Average identity of full alignment:||59 %|
|Average coverage of the sequence by the domain:||20.48 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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