Summary: Abl-interactor HHR
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Abl-interactor HHR Provide feedback
The region featured in this family is found towards the N-terminus of a number of adaptor proteins that interact with Abl-family tyrosine kinases . More specifically, it is termed the homeo-domain homologous region (HHR), as it is similar to the DNA-binding region of homeo-domain proteins . Other homeo-domain proteins have been implicated in specifying positional information during embryonic development, and in the regulation of the expression of cell-type specific genes . The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved in cytoskeletal reorganisation, but their precise role remains unclear .
Dai Z, Pendergast AM; , Genes Dev 1995;9:2569-2582.: Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. PUBMED:7590236 EPMC:7590236
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR012849
The region is found towards the N terminus of a number of adaptor proteins that interact with Abl-family tyrosine kinases [PUBMED:12011975]. More specifically, it is termed the homeo-domain homologous region (HHR), as it is similar to the DNA-binding region of homeo-domain proteins [PUBMED:7590236]. Other homeo-domain proteins have been implicated in specifying positional information during embryonic development, and in the regulation of the expression of cell-type specific genes [PUBMED:7590236]. The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved in cytoskeletal reorganisation, but their precise role remains unclear [PUBMED:12011975].
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|Cellular component||cytoplasm (GO:0005737)|
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Curation and family details
|Seed source:||Pfam-B_9732 (release 14.0)|
|Number in seed:||11|
|Number in full:||332|
|Average length of the domain:||76.80 aa|
|Average identity of full alignment:||62 %|
|Average coverage of the sequence by the domain:||17.42 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Abi_HHR domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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