Summary: PRO8NT (NUC069), PrP8 N-terminal domain
PRO8NT (NUC069), PrP8 N-terminal domain Provide feedback
The PRO8NT domain is found at the N-terminus of pre-mRNA splicing factors of PRO8 family . The NLS or nuclear localisation signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly variable proline-rich region .
Turner IA, Norman CM, Churcher MJ, Newman AJ; , RNA. 2006;12:375-386.: Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome. PUBMED:16431982 EPMC:16431982
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR012591
Pre-mRNA-processing-splicing factor 8 is a central component of the spliceosome, which may play a role in aligning the pre-mRNA 5'- and 3'-exons for ligation. It interacts with U5 snRNA, and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes. It is part of the U5 snRNP complex, and of U5.4/6 and U5.U4atac/U6atac snRNP complexes in U2- and U12-dependent spliceosomes, respectively. It is also found in a mRNA splicing-dependent exon junction complex (EJC) with SRRM1 where it interacts with U5 snRNP proteins SNRP116 and WDR57/SPF38 [PUBMED:15840809, PUBMED:9774689].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||spliceosomal complex (GO:0005681)|
|Biological process||nuclear mRNA splicing, via spliceosome (GO:0000398)|
- the number of sequences which exhibit this architecture
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Gladomain, followed by two consecutive
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Staub E|
|Author:||Staub E, Bateman A|
|Number in seed:||24|
|Number in full:||428|
|Average length of the domain:||136.00 aa|
|Average identity of full alignment:||71 %|
|Average coverage of the sequence by the domain:||7.54 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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