Summary: Cytidine and deoxycytidylate deaminase zinc-binding region
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Cytidine and deoxycytidylate deaminase zinc-binding region Provide feedback
No Pfam abstract.
Bhattacharya S, Navaratnam N, Morrison JR, Scott J, Taylor WR; , Trends Biochem Sci 1994;19:105-106.: Cytosine nucleoside/nucleotide deaminases and apolipoprotein B mRNA editing. PUBMED:8203015 EPMC:8203015
Internal database links
|Similarity to PfamA using HHSearch:||dCMP_cyt_deam_1|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013171
This region contains the zinc-binding domain of cytidine and deoxycytidylate deaminase.
Cytidine deaminase (EC) (cytidine aminohydrolase) catalyzes the hydrolysis of cytidine into uridine and ammonia while deoxycytidylate deaminase (EC) (dCMP deaminase) hydrolyzes dCMP into dUMP. Both enzymes are known to bind zinc and to require it for their catalytic activity [PUBMED:1567863, PUBMED:8428902]. These two enzymes do not share any sequence similarity with the exception of a region that contains three conserved histidine and cysteine residues which are thought to be involved in the binding of the catalytic zinc ion.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||cytidine deaminase activity (GO:0004126)|
|zinc ion binding (GO:0008270)|
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Curation and family details
|Seed source:||Pfam-B_8221 (release 16.0)|
|Number in seed:||18|
|Number in full:||900|
|Average length of the domain:||122.40 aa|
|Average identity of full alignment:||54 %|
|Average coverage of the sequence by the domain:||42.26 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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There are 2 interactions for this family. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the dCMP_cyt_deam_2 domain has been found. There are 12 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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