Summary: RNA polymerase III subunit Rpc25
RNA polymerase III subunit Rpc25 Provide feedback
Rpc25 is a strongly conserved subunit of RNA polymerase III and has homology to Rpa43 in RNA polymerase I, Rpb7 in RNA polymerase II and the archaeal RpoE subunit. Rpc25 is required for transcription initiation and is not essential for the elongating properties of RNA polymerase III .
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This tab holds annotation information from the InterPro database.
InterPro entry IPR013238
Rpc25 is a strongly conserved subunit of RNA polymerase III and has homology to Rpa43 in RNA polymerase I, Rpb7 in RNA polymerase II and the archaeal RpoE subunit. Rpc25 is required for transcription initiation and is not essential for the elongating properties of RNA polymerase III [PUBMED:15612920].
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_9841 (release 17.0)|
|Author:||Mistry J, Wood V|
|Number in seed:||33|
|Number in full:||328|
|Average length of the domain:||116.40 aa|
|Average identity of full alignment:||35 %|
|Average coverage of the sequence by the domain:||51.74 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the RNA_pol_Rbc25 domain has been found. There are 3 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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