Summary: Exportin 1-like protein
Exportin 1-like protein Provide feedback
The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1, P14068). This region is found just C-terminal to an importin-beta N-terminal domain (PF03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus [1,2].
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This tab holds annotation information from the InterPro database.
InterPro entry IPR013598
The exchange of macromolecules between the nucleus and cytoplasm takes place through nuclear pore complexes within the nuclear membrane. Active transport of large molecules through these pore complexes require carrier proteins, called karyopherins (importins and exportins), which shuttle between the two compartments.
This domain is found close to the N terminus of yeast exportin 1 (Xpo1, Crm1, SWISSPROT), as well as adjacent to the N-terminal domain of importin-beta (INTERPRO). Exportin 1 is a nuclear export receptor that translocates proteins out of the nucleus; it interacts with leucine-rich nuclear export signal (NES) sequences in proteins to be transported, as well as with RanGTP [PUBMED:9323132, PUBMED:9323123]. Importin-beta is a nuclear import receptor that translocates proteins into the nucleus; it interacts with RanGTP and importin-alpha, the latter binding with the nuclear localisation signal (NLS) sequences in proteins to be transported [PUBMED:17170104].
More information about these proteins can be found at Protein of the Month: Importins [PUBMED:].
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This example describes an architecture with one
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We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
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- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
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Curation and family details
|Seed source:||Pfam-B_4058 (release 18.0)|
|Number in seed:||59|
|Number in full:||1456|
|Average length of the domain:||147.50 aa|
|Average identity of full alignment:||19 %|
|Average coverage of the sequence by the domain:||14.93 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Xpo1 domain has been found. There are 21 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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