Summary: 7tm Chemosensory receptor
7tm Chemosensory receptor Provide feedback
This family includes a number of gustatory and odorant receptors mainly from insect species such as A. gambiae and D. melanogaster. They are classified as G-protein-coupled receptors (GPCRs), or seven-transmembrane receptors. They show high sequence divergence, consistent with an ancient origin for the family [1,2].
Robertson HM, Warr CG, Carlson JR; , Proc Natl Acad Sci U S A 2003;100:14537-14542.: Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. PUBMED:14608037 EPMC:14608037
Hill CA, Fox AN, Pitts RJ, Kent LB, Tan PL, Chrystal MA, Cravchik A, Collins FH, Robertson HM, Zwiebel LJ; , Science 2002;298:176-178.: G protein-coupled receptors in Anopheles gambiae. PUBMED:12364795 EPMC:12364795
Internal database links
|Similarity to PfamA using HHSearch:||7tm_6 Trehalose_recp|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013604
This family includes a number of gustatory and odorant receptors mainly from insect species such as Anopheles gambiae (African malaria mosquito) and Drosophila melanogaster (Fruit fly). They are classified as G-protein-coupled receptors (GPCRs), or seven-transmembrane receptors. They show high sequence divergence, consistent with an ancient origin for the family [PUBMED:14608037, PUBMED:12364795].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||integral to membrane (GO:0016021)|
|Biological process||sensory perception of taste (GO:0050909)|
- the number of sequences which exhibit this architecture
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This example describes an architecture with one
Gladomain, followed by two consecutive
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- the UniProt description of the protein sequence
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The members of this clan are families of various gustatory and odorant receptors. They are described as being seven-transmembrane receptors, and in fact all show characteristic regions of hydrophobicity on the alignment.
The clan contains the following 4 members:7tm_6 7tm_7 DUF267 Trehalose_recp
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Seed source:||Robertson H|
|Author:||Robertson H, Finn R, Fenech M|
|Number in seed:||78|
|Number in full:||1580|
|Average length of the domain:||315.20 aa|
|Average identity of full alignment:||12 %|
|Average coverage of the sequence by the domain:||89.70 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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