Summary: Respiratory burst NADPH oxidase
Respiratory burst NADPH oxidase Provide feedback
This domain is found in plant proteins such as respiratory burst NADPH oxidase proteins which produce reactive oxygen species as a defence mechanism. It tends to occur to the N-terminus of an EF-hand (PF00036), which suggests a direct regulatory effect of Ca2+ on the activity of the NADPH oxidase in plants .
Torres MA, Onouchi H, Hamada S, Machida C, Hammond-Kosack KE, Jones JD; , Plant J 1998;14:365-370.: Six Arabidopsis thaliana homologues of the human respiratory burst oxidase (gp91phox). PUBMED:9628030 EPMC:9628030
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013623
This domain is found in plant proteins such as respiratory burst NADPH oxidase proteins which produce reactive oxygen species as a defence mechanism. It tends to occur to the N terminus of an EF-hand (INTERPRO), which suggests a direct regulatory effect of Ca2+ on the activity of the NADPH oxidase in plants [PUBMED:9628030].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor (GO:0050664)|
|peroxidase activity (GO:0004601)|
|Biological process||oxidation-reduction process (GO:0055114)|
- the number of sequences which exhibit this architecture
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_2127 (release 18.0)|
|Number in seed:||28|
|Number in full:||221|
|Average length of the domain:||93.50 aa|
|Average identity of full alignment:||49 %|
|Average coverage of the sequence by the domain:||11.45 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the NADPH_Ox domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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