Summary: Rib/alpha-like repeat
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Rib/alpha-like repeat Provide feedback
The region featured in this family is found repeated in a number of bacterial surface proteins, such as Rib (P72362) and alpha (Q02192). These are expressed by group B streptococci, and Rib is thought to confer protective immunity.
Wastfelt M, Stalhammar-Carlemalm M, Delisse AM, Cabezon T, Lindahl G; , J Biol Chem 1996;271:18892-18897.: Identification of a family of streptococcal surface proteins with extremely repetitive structure. PUBMED:8702550 EPMC:8702550
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This tab holds annotation information from the InterPro database.
InterPro entry IPR012706
This entry represents a region of about 79 amino acids found tandemly repeated up to fourteen times within the proteins that contain it. The repeats lack cysteines and are highly conserved, even at the DNA level, within and between proteins [PUBMED:8702550]. Proteins containing these repeats include the Rib and alpha surface antigens of group B Streptococcus, Esp of Enterococcus faecalis (Streptococcus faecalis), and related proteins of Lactobacillus. Most members of this protein family also have the cell wall anchor motif, LPXTG, shared by many staphyloccal and streptococcal surface antigens. These repeats are thought to define protective epitopes and may play a role in generating phenotypic and genotypic variation [PUBMED:1438195].
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Curation and family details
|Seed source:||Pfam-B_3139 (release 18.0)|
|Number in seed:||16|
|Number in full:||1574|
|Average length of the domain:||66.80 aa|
|Average identity of full alignment:||33 %|
|Average coverage of the sequence by the domain:||17.85 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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