Summary: Squalene epoxidase
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This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria. SE was first cloned from Saccharomyces cerevisiae where it was named ERG1. It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway . Putative transmembrane regions are found to the protein's C-terminus.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013698
This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria. SE was first cloned from Saccharomyces cerevisiae (Baker's yeast) where it was named ERG1. It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway [PUBMED:9161422]. Putative transmembrane regions are found to the protein's C terminus.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||integral to membrane (GO:0016021)|
|Molecular function||flavin adenine dinucleotide binding (GO:0050660)|
|squalene monooxygenase activity (GO:0004506)|
|Biological process||oxidation-reduction process (GO:0055114)|
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Curation and family details
|Seed source:||Pfam-B_3107 (release 18.0)|
|Number in seed:||13|
|Number in full:||429|
|Average length of the domain:||239.90 aa|
|Average identity of full alignment:||39 %|
|Average coverage of the sequence by the domain:||51.57 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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