Summary: Adenylate cyclase G-alpha binding domain
Adenylate cyclase G-alpha binding domain Provide feedback
This fungal domain is found in adenylate cyclase and interacts with the alpha subunit of heterotrimeric G proteins .
Ivey FD, Hoffman CS; , Proc Natl Acad Sci U S A 2005;102:6108-6113.: Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathway. PUBMED:15831585 EPMC:15831585
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This tab holds annotation information from the InterPro database.
InterPro entry IPR013716
Adenylate cyclase catalyses the conversion of ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate. It plays an essential role in the regulation of cellular metabolism by catalysing the synthesis of a second messenger, cAMP. G protein-mediated signalling is implicated in yeast and fungal cAMP pathways. The cAMP-PKA pathway consists of an extracellular ligand-sensitive G protein-coupled receptor, a G protein signal transmitter, and the effector adenylate cyclase. The product of adenylate cyclase, cAMP, acts as an intracellular second messenger [PUBMED:16924114].
GTP-bound RAS2 is required to elicit magnesium-dependent adenylyl cyclase activity in Saccharomyces cerevisiae. In Schizosaccharomyces pombe, however, the cyclase is probably not regulated by RAS proteins, but is activated by git1.
In S. pombe, Gpa2 Galpha binds an N-terminal domain of adenylate cyclase, comprising a moderately conserved sequence, which is within a region that is poorly related to other fungal adenylate cyclases. Adenylate cyclase is directly activated by a fungal G protein, which suggests a distinct activation mechanism from that of mammals [PUBMED:15831585].
This fungal domain interacts with the alpha subunit of heterotrimeric G proteins [PUBMED:15831585].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||magnesium ion binding (GO:0000287)|
|adenylate cyclase activity (GO:0004016)|
|Biological process||cAMP biosynthetic process (GO:0006171)|
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Curation and family details
|Author:||Mistry J, Wood V|
|Number in seed:||19|
|Number in full:||100|
|Average length of the domain:||51.20 aa|
|Average identity of full alignment:||30 %|
|Average coverage of the sequence by the domain:||2.63 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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