Summary: Transcription factor PAP1
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Transcription factor PAP1 Provide feedback
The transcription factor Pap1 regulates antioxidant-gene transcription in response to H2O2 . This region is cysteine rich. Alkylation of cysteine residues following treatment with a cysteine alkylating agent can mask the accessibility of the nuclear exporter Crm1, triggering nuclear accumulation and Pap1 dependent transcriptional expression .
Vivancos AP, Castillo EA, Biteau B, Nicot C, Ayte J, Toledano MB, Hidalgo E; , Proc Natl Acad Sci U S A. 2005;102:8875-8880.: A cysteine-sulfinic acid in peroxiredoxin regulates H2O2-sensing by the antioxidant Pap1 pathway. PUBMED:15956211 EPMC:15956211
Castillo EA, Ayte J, Chiva C, Moldon A, Carrascal M, Abian J, Jones N, Hidalgo E; , Mol Microbiol. 2002;45:243-254.: Diethylmaleate activates the transcription factor Pap1 by covalent modification of critical cysteine residues. PUBMED:12100563 EPMC:12100563
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013910
The transcription factor Pap1 regulates antioxidant-gene transcription in response to H2O2 [PUBMED:15956211]. This region is cysteine rich. Alkylation of cysteine residues following treatment with a cysteine alkylating agent can mask the accessibility of the nuclear exporter Crm1, triggering nuclear accumulation and Pap1 dependent transcriptional expression [PUBMED:12100563].
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Curation and family details
|Seed source:||Pfam-B_20528 (release 18.0)|
|Author:||Mistry J, Wood V|
|Number in seed:||10|
|Number in full:||181|
|Average length of the domain:||264.60 aa|
|Average identity of full alignment:||22 %|
|Average coverage of the sequence by the domain:||57.66 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PAP1 domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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