Summary: PLAC (protease and lacunin) domain
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PLAC (protease and lacunin) domain Provide feedback
The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin .
Nardi JB, Martos R, Walden KK, Lampe DJ, Robertson HM; , Insect Biochem Mol Biol. 1999;29:883-897.: Expression of lacunin, a large multidomain extracellular matrix protein, accompanies morphogenesis of epithelial monolayers in Manduca sexta. PUBMED:10528409 EPMC:10528409
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR010909
The PLAC (protease and lacunin) domain is a six-cysteine region of about 40 residues that is present at or near the C-terminal of various enzymes and matrix proteins, including: mammalian PACE4 (paired basic amino acid cleaving enzyme 4), mammalian PCSK5 (proprotein convertase subtilisin/kexin type 5), mammalian metalloproteinases ADAMTS-2, -3, -10, -12, -14, -16, -17, and -19, and manduca Sexta matrix protein lacunin [PUBMED:11867212]. The PLAC domain is often associated with other domains, such as the thrombospondin type I repeat (TSP1) (INTERPRO), the Kunitz proteinase inhibitor domain (INTERPRO), the Ig-like domain (INTERPRO), the WAP domain (INTERPRO), the subtilase domain (INTERPRO), or the ADAM-type metalloprotease domain (INTERPRO).
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|Molecular function||peptidase activity (GO:0008233)|
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Curation and family details
|Seed source:||Rawlings ND|
|Author:||Mistry J, Rawlings ND|
|Number in seed:||29|
|Number in full:||739|
|Average length of the domain:||34.10 aa|
|Average identity of full alignment:||37 %|
|Average coverage of the sequence by the domain:||3.34 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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