Summary: Switch protein XOL-1, N-terminal
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Switch protein XOL-1, N-terminal Provide feedback
Members of this family, which are required for the formation of the active site of the sex-determining protein Xol-1, adopt a secondary structure consisting of five alpha helices and six antiparallel beta sheets, in a beta-alpha-beta-beta-beta-alpha-beta-alpha-alpha-alpha-beta arrangement. The fold of this family is similar to that found in ribosomal protein S5 domain 2-like .
Luz JG, Hassig CA, Pickle C, Godzik A, Meyer BJ, Wilson IA; , Genes Dev. 2003;17:977-990.: XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. PUBMED:12672694 EPMC:12672694
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR015192
This domain, found in sex-determining protein Xol-1, adopts a secondary structure consisting of five alpha helices and six antiparallel beta sheets, in a beta-alpha-beta-beta-beta-alpha-beta-alpha-alpha-alpha-beta arrangement. The fold of this family is similar to that found in ribosomal protein S5 domain 2-like [PUBMED:12672694]. The active site of the enzyme is found at the interface between this domain and the C-terminal GHMP-like domain.
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Curation and family details
|Number in seed:||2|
|Number in full:||12|
|Average length of the domain:||147.40 aa|
|Average identity of full alignment:||27 %|
|Average coverage of the sequence by the domain:||40.39 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Xol-1_N domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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