Summary: FimH, mannose binding
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FimH, mannose binding Provide feedback
Members of this family adopt a secondary structure consisting of a beta sandwich, with nine strands arranged in two sheets in a Greek key topology. They are predominantly found in bacterial mannose-specific adhesins, since they are capable of binding to D-mannose .
Hung CS, Bouckaert J, Hung D, Pinkner J, Widberg C, DeFusco A, Auguste CG, Strouse R, Langermann S, Waksman G, Hultgren SJ; , Mol Microbiol. 2002;44:903-915.: Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection. PUBMED:12010488 EPMC:12010488
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR015243
This domain adopts a secondary structure consisting of a beta sandwich, with nine strands arranged in two sheets in a Greek key topology. It is predominantly found in bacterial mannose-specific adhesins, and is capable of binding to D-mannose [PUBMED:12010488].
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Curation and family details
|Number in seed:||6|
|Number in full:||806|
|Average length of the domain:||143.80 aa|
|Average identity of full alignment:||68 %|
|Average coverage of the sequence by the domain:||49.23 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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There are 4 interactions for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the FimH_man-bind domain has been found. There are 37 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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