Summary: Fimbrial adhesin F17-AG, lectin domain
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Fimbrial adhesin F17-AG, lectin domain Provide feedback
Members of this family are carbohydrate-specific lectin domains found in bacterial fimbrial adhesins. They adopt a compact, elongated structure consisting of a beta-sandwich with two major sheets: one consisting of five long strands in mixed orientations, and a front sheet with four antiparallel strands, forming an immunoglobin-like fold .
Buts L, Bouckaert J, De Genst E, Loris R, Oscarson S, Lahmann M, Messens J, Brosens E, Wyns L, De Greve H; , Mol Microbiol. 2003;49:705-715.: The fimbrial adhesin F17-G of enterotoxigenic Escherichia coli has an immunoglobulin-like lectin domain that binds N-acetylglucosamine. PUBMED:12864853 EPMC:12864853
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR015303
This entry represents the carbohydrate-specific lectin domain found in bacterial fimbrial adhesins. It adopts a compact, elongated structure consisting of a beta-sandwich with two major sheets: one consisting of five long strands in mixed orientations, and a front sheet with four antiparallel strands, forming an immunoglobin-like fold [PUBMED:12864853].
|Cellular component||pilus (GO:0009289)|
|Biological process||adhesion to host (GO:0044406)|
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Curation and family details
|Number in seed:||2|
|Number in full:||22|
|Average length of the domain:||167.20 aa|
|Average identity of full alignment:||50 %|
|Average coverage of the sequence by the domain:||47.14 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Fim-adh_lectin domain has been found. There are 15 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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