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6  structures 15  species 1  interaction 38  sequences 1  architecture

Family: Feld-I_B (PF09252)

Summary: Allergen Fel d I-B chain

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This is the Wikipedia entry entitled "Fel d 1". More...

Fel d 1 Edit Wikipedia article

Major allergen I polypeptide chain 2
Fel d 1.png
Crystallographic structure of the Fel d 1 dimer, the primary allergen present in cat saliva.[1]
Identifiers
Symbol CH2
Alt. symbols Fel d I, AG4, Allergen Cat-1
Entrez 677879
PDB 1PUO (RCSB PDB PDBe PDBj)
UniProt P30440
Allergen Fel d I-B chain
PDB 2ejn EBI.jpg
structural characterization of the tetrameric form of the major cat allergen fel d 1
Identifiers
Symbol Feld-I_B
Pfam PF09252
Pfam clan CL0370
InterPro IPR015332
SCOP 1puo
SUPERFAMILY 1puo

Fel d 1 is a protein that in cats is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes.[2][3]

Fel d 1, produced largely in cat saliva and sebaceous glands, is the primary allergen present on cats and kittens.[1] The protein is of an unknown function to the animal but causes an IgG or IgE reaction in sensitive humans (either as an allergic or asthmatic response). Removal of soft surfaces in the home (carpet, furniture), frequent washings of bed linens, HEPA filters and even washing cats has been proven to reduce the amounts of Fel d 1 present in the home.

Neutered males produce Fel d 1 in levels similar to females (both intact and spayed females produce Fel d 1 in similar levels). Even though females and neutered males produce Fel d 1 in lower levels, they still produce enough to cause allergic symptoms in sensitive individuals.

Structure[edit]

The complete quaternary structure of Fel d 1 has been determined.[1] The allergen is a tetrameric glycoprotein consisting of two disulfide-linked heterodimers of [chains 1 and 2. Fel d 1 chains 1 and 2 share structural similarity with uteroglobin, a secretoglobin superfamily member; chain 2 is a glycoprotein with N-linked oligosaccharides. Both chains share an all alpha-helical structure.[1]

See also[edit]

References[edit]

  1. ^ a b c d PDB 1PUO; Kaiser L, Grönlund H, Sandalova T, Ljunggren HG, van Hage-Hamsten M, Achour A, Schneider G (September 2003). "The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family". J. Biol. Chem. 278 (39): 37730–5. doi:10.1074/jbc.M304740200. PMID 12851385. 
  2. ^ Morgenstern JP, Griffith IJ, Brauer AW, Rogers BL, Bond JF, Chapman MD, Kuo MC (November 1991). "Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein sequence analysis and cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9690–4. doi:10.1073/pnas.88.21.9690. PMC 52784. PMID 1946388. 
  3. ^ Griffith IJ, Craig S, Pollock J, Yu XB, Morgenstern JP, Rogers BL (April 1992). "Expression and genomic structure of the genes encoding FdI, the major allergen from the domestic cat". Gene 113 (2): 263–8. doi:10.1016/0378-1119(92)90405-E. PMID 1572548. 

This article incorporates text from the public domain Pfam and InterPro IPR015332


This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Allergen Fel d I-B chain Provide feedback

Members of this family of cat allergens adopt a helical structure consisting of eight alpha helices, in a Uteroglobin-like fold. They are one of the most important causes of allergic asthma worldwide [1].

Literature references

  1. Kaiser L, Gronlund H, Sandalova T, Ljunggren HG, van Hage-Hamsten M, Achour A, Schneider G; , J Biol Chem. 2003;278:37730-37735.: The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family. PUBMED:12851385 EPMC:12851385


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR015332

Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen, stings, drugs, or food) that, in most people, result in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans. The nomenclature system uses the first three letters of the genus, followed by the first letter of the species name, followed by a number (additional letters can be added to the name as required to discriminate between similar designations).

Fel d 1 is allergen 1 from Felis silvestris catus (Cat), which is an important agent in human allergic reactions [PUBMED:17543334]. The protein is expressed in saliva and sebaceous glands. The complete primary structure of Fel d 1 has been determined [PUBMED:12851385]. The allergen is tetrameric glycoprotein consisting of two disulphide-linked heterodimers of chains 1 and 2, which have been shown to be encoded by different genes. Fel d 1 chains 1 and 2 share structural similarity with uteroglobin, a secretoglobin superfamily member; chain 2 is a glycoprotein with N-linked oligosaccharides.

This entry represents Fel d 1 chain 2.

Gene Ontology

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Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Uteroglobin (CL0370), which has the following description:

Members of this superfamily are disulfide-linked dimers of two identical chains, with 4 helices in each. They constitute important new cat, rat and rabbit allergens that are contributing to asthma world-wide.

The clan contains the following 2 members:

Feld-I_B Uteroglobin

Alignments

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External links

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Pfam alignments:

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Trees

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Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: pdb_1puo
Previous IDs: none
Type: Domain
Author: Sammut SJ
Number in seed: 10
Number in full: 38
Average length of the domain: 66.30 aa
Average identity of full alignment: 42 %
Average coverage of the sequence by the domain: 64.32 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 24.0 24.0
Trusted cut-off 25.1 24.8
Noise cut-off 22.8 21.7
Model length: 67
Family (HMM) version: 5
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Species distribution

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Interactions

There is 1 interaction for this family. More...

Feld-I_B

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Feld-I_B domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.

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