Summary: Sas10 C-terminal domain
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Sas10 C-terminal domain Provide feedback
Sas10 is an Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in the production of the 18S rRNA and assembly of the small ribosomal subunit.
Dragon F, Gallagher JE, Compagnone-Post PA, Mitchell BM, Porwancher KA, Wehner KA, Wormsley S, Settlage RE, Shabanowitz J, Osheim Y, Beyer AL, Hunt DF, Baserga SJ; , Nature 2002;0:0-0.: A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. PUBMED:12068309 EPMC:12068309
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR018972
This entry represents the C-terminal domain of the Something about silencing protein 10 (Sas10), which is essential for gene silencing and has a role in the structure of silenced chromatin [PUBMED:9611201, PUBMED:12756328]. Sas10 plays a role in the developing brain, and may bind RNA. SAS10 from Saccharomyces cerevisiae (Baker's yeast) is primarily required at the G2/M phase and is essential for viability, being involved in nucleolar processing of pre-18S ribosomal RNA as part of the ribosomal small subunit (SSU) processome [PUBMED:17330950].
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|Cellular component||nucleus (GO:0005634)|
|Biological process||gene silencing (GO:0016458)|
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Curation and family details
|Seed source:||Bateman A|
|Number in seed:||35|
|Number in full:||308|
|Average length of the domain:||76.10 aa|
|Average identity of full alignment:||46 %|
|Average coverage of the sequence by the domain:||13.75 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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