Summary: NurA domain
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NurA domain Provide feedback
This family includes NurA a nuclease exhibiting both single-stranded endonuclease activity and 5'-3' exonuclease activity on single-stranded and double-stranded DNA from the hyperthermophilic archaeon Sulfolobus acidocaldarius .
Iyer LM, Makarova KS, Koonin EV, Aravind L; , Nucleic Acids Res. 2004;32:5260-5279.: Comparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packaging. PUBMED:15466593 EPMC:15466593
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR018977
This domain is found in several uncharacterised proteins and in NurA, a nuclease exhibiting both single-stranded endonuclease activity and 5'-3' exonuclease activity on single-stranded and double-stranded DNA from the hyperthermophilic archaeon Sulfolobus acidocaldarius [PUBMED:12052775].
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Iyer LM|
|Author:||Iyer LM, Bateman A|
|Number in seed:||65|
|Number in full:||438|
|Average length of the domain:||278.20 aa|
|Average identity of full alignment:||14 %|
|Average coverage of the sequence by the domain:||74.78 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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The tree shows the occurrence of this domain across different species. More...
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There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the NurA domain has been found. There are 10 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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