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0  structures 198  species 0  interactions 475  sequences 1  architecture

Family: Pathogen_betaC1 (PF09593)

Summary: Beta-satellite pathogenicity beta C1 protein

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Beta-satellite pathogenicity beta C1 protein Provide feedback

Cotton leaf-curl disease - CLCuD - is of major economic importance in cotton-growing areas of the far-east. The infectious agent appears to be a single-stranded DNA molecule of approx 1350 nucleotides in length, which, when inoculated with the Begomovirus into cotton, induces symptoms typical of CLCuD. This molecule requires the Begomovirus for replication and encapsidation [1]. DNA beta encodes a single protein, betaC1. The intracellular distribution of betaC1 is consistent with the hypothesis that it has a role in transporting the DNA A of Begomovirus from the nuclear site of replication to the plasmodesmatal exit sites of the infected cell. The DNA beta-encoded protein, betaC1, is the determinant of both pathogenicity and suppression of gene silencing [3].

Literature references

  1. Briddon RW, Mansoor S, Bedford ID, Pinner MS, Saunders K, Stanley J, Zafar Y, Malik KA, Markham PG; , Virology. 2001;285:234-243.: Identification of dna components required for induction of cotton leaf curl disease. PUBMED:11437658 EPMC:11437658

  2. Mansoor S, Briddon RW, Bull SE, Bedford ID, Bashir A, Hussain M, Saeed M, Zafar Y, Malik KA, Fauquet C, Markham PG; , Arch Virol. 2003;148:1969-1986.: Cotton leaf curl disease is associated with multiple monopartite begomoviruses supported by single DNA beta. PUBMED:14551819 EPMC:14551819

  3. Saeed M, Zafar Y, Randles JW, Rezaian MA; , J Gen Virol. 2007;88:2881-2889.: A monopartite begomovirus-associated DNA beta satellite substitutes for the DNA B of a bipartite begomovirus to permit systemic infection. PUBMED:17872543 EPMC:17872543


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR018583

Cotton leaf-curl disease - CLCuD - is of major economic importance in cotton-growing areas of the far-east. The infectious agent appears to be a single-stranded DNA molecule of approx 1350 nucleotides in length, which, when inoculated with the Begomovirus into cotton, induces symptoms typical of CLCuD. This molecule requires the Begomovirus for replication and encapsidation [PUBMED:11437658]. DNA beta encodes a single protein, betaC1. The intracellular distribution of betaC1 is consistent with the hypothesis that it has a role in transporting the DNA A of Begomovirus from the nuclear site of replication to the plasmodesmatal exit sites of the infected cell. The DNA beta-encoded protein, betaC1, is the determinant of both pathogenicity and suppression of gene silencing [PUBMED:17872543].

Domain organisation

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Alignments

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

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(36)
Full
(475)
Representative proteomes NCBI
(438)
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  Seed
(36)
Full
(475)
Representative proteomes NCBI
(438)
Meta
(0)
RP15
(0)
RP35
(0)
RP55
(0)
RP75
(0)
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(36)
Full
(475)
Representative proteomes NCBI
(438)
Meta
(0)
RP15
(0)
RP35
(0)
RP55
(0)
RP75
(0)
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

Pfam alignments:

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Curation and family details

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Curation View help on the curation process

Seed source: Pfam-B_991 (release 21.0)
Previous IDs: Phage_C1;
Type: Domain
Author: Coggill P
Number in seed: 36
Number in full: 475
Average length of the domain: 116.10 aa
Average identity of full alignment: 44 %
Average coverage of the sequence by the domain: 96.96 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 46.8 43.6
Noise cut-off 19.7 19.2
Model length: 117
Family (HMM) version: 5
Download: download the raw HMM for this family

Species distribution

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