Summary: 26S proteasome subunit RPN7
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26S proteasome subunit RPN7 Provide feedback
RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity . The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.
Isono E, Saeki Y, Yokosawa H, Toh-e A; , J Biol Chem. 2004;279:27168-27176.: Rpn7 Is required for the structural integrity of the 26 S proteasome of Saccharomyces cerevisiae. PUBMED:15102831 EPMC:15102831
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This tab holds annotation information from the InterPro database.
InterPro entry IPR019585
This entry represents the regulatory subunit RPN7 (known as the non-ATPase regulatory subunit 6 in higher eukaryotes) of the 26S proteasome. This entry also matches the evolutionarily related subunit 1 of the COP9 signalosome complex (CSN) from Arabidopsis [PUBMED:11742986].
The 26S proteasome plays a major role in ATP-dependent degradation of ubiquitinated proteins. Substrate specificity is conferred by the regulatory particle (RP), which can dissociate into stable lid and base subcomplexes. The regulatory subunit RPN7 is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae (Baker's yeast) to be required for structural integrity [PUBMED:15102831].
The COP9 signalosome is a conserved protein complex composed of eight subunits, where Individual subunits of the complex have been linked to various signal transduction pathways leading to gene expression and cell cycle control [PUBMED:11114242]. The overall organisation and the amino acid sequences of the COP9 signalosome subunits resemble the lid subcomplex of the 19 S regulatory particle for the 26 S proteasome [PUBMED:9741626]. COP9 subunit 1 (CSN1 or GPS1) of the COP9 complex is an essential subunit of the complex with regard to both structural integrity and functionality. The N-terminal region of subunit 1 (CSN1-N) can inhibit c-fos expression from either a transfected template or a chromosomal transgene (fos-lacZ), and may contain the activity domain that confers most of the repression functions of CSN1. The C-terminal region of subunit 1 (CSN1-C) allows integration of the protein into the COP9 signalosome.
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|Seed source:||Pfam-B_4112 (release 22.0)|
|Author:||Mistry J, Wood V|
|Number in seed:||63|
|Number in full:||673|
|Average length of the domain:||171.80 aa|
|Average identity of full alignment:||30 %|
|Average coverage of the sequence by the domain:||40.18 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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