Summary: Homer-binding domain of metabotropic glutamate receptor
Homer-binding domain of metabotropic glutamate receptor Provide feedback
This is the proline-rich region of metabotropic glutamate receptor proteins that binds Homer-related synaptic proteins. The Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R) that appears to be due to the proline-rich "Homer ligand" (PPXXFr). Activation of PI turnover triggers intracellular calcium release . MGluR function is altered in the mouse model of human Fragile X syndrome mental retardation, a disorder caused by loss of function mutations in the Fragile X mental retardation gene Fmr1. Homer 3 (and to a lesser extent Homer 1b/c) has been shown to form a multimeric complex with mGlu1a and the IP3 receptor, indicating that Homers may play a role in the localisation of receptors to their signalling partners .
Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF; , Neuron. 1998;21:717-726.: Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. PUBMED:9808459 EPMC:9808459
Ronesi JA, Huber KM; , J Neurosci. 2008;28:543-547.: Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation. PUBMED:18184796 EPMC:18184796
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019588
This entry represents the proline-rich region of metabotropic glutamate receptor proteins that bind Homer-related synaptic proteins.
Metabotropic glutamate receptors function as receptors for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
The Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R) that appears to be due to the proline-rich Homer ligand (PPXXFr). Activation of PI turnover triggers intracellular calcium release [PUBMED:9808459]. Metabotropic glutamate receptor (MGluR) function is altered in the mouse model of human Fragile X syndrome mental retardation, a disorder caused by loss of function mutations in the Fragile X mental retardation gene Fmr1. Homer 3 (and to a lesser extent Homer 1b/c) has been shown to form a multimeric complex with mGlu1a and the IP3 receptor, indicating that Homers may play a role in the localisation of receptors to their signalling partners [PUBMED:18184796].
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Curation and family details
|Seed source:||Pfam-B_17370 (release 22.0)|
|Number in seed:||5|
|Number in full:||118|
|Average length of the domain:||50.30 aa|
|Average identity of full alignment:||66 %|
|Average coverage of the sequence by the domain:||5.05 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the GluR_Homer-bdg domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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