Summary: Putative bacterial sensory transduction regulator
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Putative bacterial sensory transduction regulator Provide feedback
YbjN is a putative sensory transduction regulator protein found in Proteobacteria. As it is a multi-copy suppressor of the coenzyme A-associated temperature sensitivity in temperature-sensitive mutant strains of Escherichia coli the suggestion is that it both helps CoA-A1 and possibly works as a general stabiliser for some other unstable proteins . This family was expanded to subsume other related families: DUF1790, DUF1821 and DUF2596.
Chen X, Shen D, Zhou B; , Biochem Biophys Res Commun. 2006;345:834-842.: Analysis of the temperature-sensitive mutation of Escherichia coli pantothenate kinase reveals YbjN as a possible protein stabilizer. PUBMED:16701556 EPMC:16701556
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019660
YbjN is a putative sensory transduction regulator protein found in Proteobacteria. As it is a multi-copy suppressor of the coenzyme A-associated temperature sensitivity in temperature-sensitive mutant strains of Escherichia coli the suggestion is that it both helps CoA-A1 and possibly works as a general stabiliser for some other unstable proteins [PUBMED:16701556].
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The translocation of pathogenic proteins into a host cell is mediated by the type III secretory system. A component of this system is a chaperone, which binds to the protein which is going to be secreted in the bacterial cytosol and is involved in translocation of the secreted protein, although the chaperone is not translocated itself. An individual chaperone associates with one or two specific proteins . There are a large number of type III secretory system chaperones, which are small acidic proteins and exhibit significant sequence divergence. This clan groups type III secretory system chaperones. Members with a known structure form small compact globular domains with an alpha-beta(3)- alpha-beta(2)-alpha like organisation .
The clan contains the following 3 members:CesT Chaperone_III YbjN
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Curation and family details
|Author:||Mistry J, Coggill P, Bateman A|
|Number in seed:||185|
|Number in full:||1845|
|Average length of the domain:||127.10 aa|
|Average identity of full alignment:||20 %|
|Average coverage of the sequence by the domain:||69.51 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the YbjN domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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