Summary: Orexigenic neuropeptide Qrfp/P518
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Orexigenic neuropeptide Qrfp/P518 Provide feedback
Qrfp/P518 has a direct role in maintaining bone mineral density . Qrfp has also found to be important in energy homeostasis by regulating appetite and energy expenditure in mice . The c-terminal 28 residues are the functional 26RFa .
Zhang Q, Qiu P, Arreaza MG, Simon JS, Golovko A, Laverty M, Vassileva G, Gustafson EL, Rojas-Triana A, Bober LA, Hedrick JA, Monsma FJ Jr, Greene JR, Bayne ML, Murgolo NJ; , Genomics. 2007;90:629-635.: P518/Qrfp sequence polymorphisms in SAMP6 osteopenic mouse. PUBMED:17869477 EPMC:17869477
Moriya R, Sano H, Umeda T, Ito M, Takahashi Y, Matsuda M, Ishihara A, Kanatani A, Iwaasa H; , Endocrinology. 2006;147:2916-2922.: RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice. PUBMED:16543370 EPMC:16543370
Chartrel N, Dujardin C, Anouar Y, Leprince J, Decker A, Clerens S, Do-Rego JC, Vandesande F, Llorens-Cortes C, Costentin J, Beauvillain JC, Vaudry H; , Proc Natl Acad Sci U S A. 2003;100:15247-15252.: Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. PUBMED:14657341 EPMC:14657341
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR024565
QRFP/P518 has a direct role in maintaining bone mineral density [PUBMED:17869477]. QRFP has also found to be important in energy homeostasis by regulating appetite and energy expenditure in mice [PUBMED:16543370]. The C-terminal 28 residues are the functional neuropeptide 26RFa [PUBMED:14657341].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||orexigenic neuropeptide QRFP receptor binding (GO:0031854)|
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Curation and family details
|Author:||Pollington J, Finn RD|
|Number in seed:||3|
|Number in full:||30|
|Average length of the domain:||123.40 aa|
|Average identity of full alignment:||60 %|
|Average coverage of the sequence by the domain:||97.11 %|
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build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
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