Summary: Scaffold protein Ste5-Fus5 binding region
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Scaffold protein Ste5-Fus5 binding region Provide feedback
This family of proteins represents the Fus5 binding region of Ste5. Ste5 functions in the yeast mating pathway and is required for signalling through the mating response MAPK pathway. Ste5 has separate binding sites for each member of the MAPK cascade. This region of Ste5 allosterically activates autophosphroylation of Fus3, a mitogen-activated protein kinase. Auto-activated Fus3 has a negative regulatory role, and promotes Ste5 phosphorylation which leads to a decrease in pathway transcriptional output .
Bhattacharyya RP, Remenyi A, Good MC, Bashor CJ, Falick AM, Lim WA; , Science. 2006;311:822-826.: The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway. PUBMED:16424299 EPMC:16424299
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This tab holds annotation information from the InterPro database.
InterPro entry IPR021651
This family of proteins represents the Fus5 binding domain of Ste5. Ste5 functions in the yeast mating pathway and is required for signalling through the mating response MAPK pathway. Ste5 has separate binding sites for each member of the MAPK cascade. This region of Ste5 allosterically activates autophosphroylation of Fus3, a mitogen-activated protein kinase. Auto-activated Fus3 has a negative regulatory role, and promotes Ste5 phosphorylation which leads to a decrease in pathway transcriptional output [PUBMED:16424299].
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Curation and family details
|Number in seed:||2|
|Number in full:||10|
|Average length of the domain:||30.00 aa|
|Average identity of full alignment:||98 %|
|Average coverage of the sequence by the domain:||3.34 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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